AD/ADRD Focus Pilot Core (Core F) Project Summary The overarching goal of the Alzheimer's Disease and Alzheimer's Disease Related Dementias (AD/ADRD) Focus Pilot Core (Core F) is to promote the advancement of science and engineering for predictive analytics, for clinical decision support, or for the care of adults with AD/ADRD. To advance this mission, we will solicit, fund, and support pilot projects focused on innovative technologies and AI approaches for several important aspects of aging in place, and, more specifically, projects that respond to the specific challenges of those with an AD/ADRD diagnosis. To name a few, we will fund pilots focused on developing AI methods and software for the processing and integration of data from home monitoring technology with clinical data from EHRs, on analysis of integrated data using automated machine learning, or on incorporating validated AI models into clinical workflows for decision support within a health system, in the home, or any other point of care. The core will be led by Dr. Graciela Gonzalez-Hernandez, Associate Professor of Informatics and Senior Faculty of the Institute of Biomedical Informatics (IBI) at the University of Pennsylvania, and Director of the Health Language Processing (HLP) Center within the institute. With over 100 publications in prestigious journals and conferences, Dr Gonzalez-Hernandez’s 19 years of academic career plus 5 more in industry bring a unique perspective with respect to the integration of research and applicable software systems, and their adequate construction and distribution. She was Director of the Database Management and Biostatistics Core for the NIH-funded Arizona Alzheimer’s Disease Center for 8 years (2008 to 2016), where she helped organize the annual selection of Pilot Projects. She is a member of the NLM Board of Scientific Advisors (effective as of the Spring of 2021) and of the NIH Biodata Management and Analysis (BDMA) study section since 2019. She was previously a member of the NIH/NLM BLIRC study section (2009-2013). Overall, in line with the overarching theme of the PennAITech Collaborative, Core F seeks to provide comprehensive, integrated, and continuous support and promotion of Pilot projects that connect novel technologies for monitoring aging adults in the home with research activities and clinical care, specifically aimed at addressing the acute needs of the AD/ADRD patients and their caregivers and the specific nuances and progression of AD/ADRD. To our knowledge, a comprehensive pipeline from home to clinic and back that addresses the many challenges of AD/ADRD does not yet exist. Building and extending this pipeline will be central to our pilot funding program. The AD/ADRD Pilot Core has the following Specific Aims: (1) to solicit, review, and support pilot studies that develop or advance the use of AI and technology for AD/ADRD predictive analytics, clinical decision support, or the care of adults with AD/ADRD, (2) to foster collabo...