PROJECT SUMMARY The goal of the Penn Artificial Intelligence and Technology (PennAITech) Collaboratory is to identify, develop, evaluate, commercialize, and disseminate innovative technology for monitoring aging adults and persons with Alzheimer's disease and Alzheimer’s disease related dementias (AD/ADRD) in their home environment and the artificial intelligence (AI) methods and software for analyzing data generated by those technologies for improving clinical care. This will help aging Americans live safe, social, and engaged lives. To date, the science of AI and monitoring technologies has often outpaced existing ethical and policy frameworks, and the unique ethical and policy implications for older adults, including older adults experiencing cognitive decline/impairment and their care partners, have largely been overlooked. Therefore, there is a critical need for ethics and policy scholarship—in conversation both with the science of AI and monitoring technology and also with the science of aging and AD/ADRD—throughout the research phase, as well as during its translation into viable interventions. To address this need, the Ethics and Policy Core will work in close collaboration with the other PennAITech Collaboratory Cores with a focus on four key issues: promoting the autonomy of older adults by balancing considerations of usefulness and intrusiveness; protecting older adults in light of vulnerability due to cognitive and functional decline; mitigating bias and addressing health disparities, such as racial disparities and urban-rural disparities; and safeguarding the data privacy of older adults. In order to accomplish this, the Ethics and Policy Core has three aims: (1) to provide guidance and training to PennAITech Collaboratory-funded pilot project leaders, trainees, and industry leaders on ethical and policy issues encountered in researching and developing AI methods and technologies for healthy aging; (2) to examine the ethical and policy barriers to using AI methods and technologies for healthy aging from the perspective of diverse stakeholders, including healthy older adults, adults with AD/ADRD, and care partners; and (3) to serve as a national resource for the research community by disseminating guidelines and best practices related to developing AI methods and technologies for healthy aging and translating them into care with a focus on healthy older adults, adults with AD/ADRD, and care partners. This innovative and impactful Core will be led by Emily A. Largent, JD, PhD, RN, an authority on bioethical and policy issues in research and care involving older adults and persons living with AD/ADRD, and it will engage a multidisciplinary team of experts to reach its overarching goal.