# Vascular Contributions to Cognitive Impairment after Adverse Pregnancy Outcomes: the nuMoM2b-Heart Health Study

> **NIH NIH R01** · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2021 · $827,316

## Abstract

PROJECT SUMMARY/ABSTRACT
Vascular contributions to cognitive impairment and dementia (VCID) are now recognized as a key pathogenic
factor in dementia, and represent a promising target for intervention. Adverse pregnancy outcomes (APOs),
such as preeclampsia, preterm delivery, and fetal growth restriction, are associated with future maternal
cardiovascular and cerebrovascular risk. However, the impact of APOs on maternal VCID remains
unexamined. Most existing women's cardiovascular and aging cohorts lack rigorously phenotyped,
prospectively collected pregnancy data, and the impact of maternal factors that may predispose to both APOs
and VCID is not well understood. From 2010-2013, the Nulliparous Pregnancy Outcomes Study Monitoring
Mothers-to-be (nuMoM2b) study enrolled a diverse cohort of 10,037 healthy women at 8 US academic medical
centers, who were followed from early in conception through the delivery of their first child. Several years later,
the Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-be Heart Health Study (nuMoM2b-HHS)
brought back 4,475 nuMoM2b women for a second study wave, to characterize subsequent pregnancy
outcomes and accumulation of cardiovascular risk factors following pregnancy. A third study wave of in-person
visits will begin in early 2022. In this ancillary study, we propose to conduct neurocognitive assessments on all
nuMoM2b-HHS participants during this third study wave. We will perform brain magnetic resonance imaging
(MRI) on a sub-cohort of 250 women followed at the Columbia University Irving Medical Center study site,
including all who experienced APOs in the index pregnancy. The overall goal of the study is to capitalize on
this unique obstetric cohort to determine the impact of APOs on long term maternal VCID, through the
following specific aims: (1) Investigate the impact of APOs on maternal cognition 10-15 years after delivery by
comparing global cognition scores between women who experienced APOs and women who did not; (2)
Determine the impact of APOs on MRI biomarkers of maternal VCID, including white matter hyperintensity
volume and additional markers of cerebral small vessel disease. We hypothesize that the association of APOs
with VCID markers will be partially mediated by development of new hypertension after the index pregnancy.
As an exploratory aim, we will use deep pregnancy phenotyping, including maternal characteristics, biomarkers
of ischemic placental disease and APOs, to create a VCID prediction model. This will be the first US study to
use prospectively collected pregnancy data to investigate the impact of APOs, a sex-specific vascular risk
factor, on VCID in women. Understanding the effects of APOs on early markers of VCID could help us identify
women early in life who are at higher risk of dementia, and develop preventive strategies to thwart the
progression of cognitive decline in this population. In addition, the collection of neurocognitive assessments on
the entire nuMoM2b-HH...

## Key facts

- **NIH application ID:** 10275504
- **Project number:** 1R01NS122815-01
- **Recipient organization:** COLUMBIA UNIVERSITY HEALTH SCIENCES
- **Principal Investigator:** Eliza C Miller
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $827,316
- **Award type:** 1
- **Project period:** 2021-07-15 → 2026-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10275504

## Citation

> US National Institutes of Health, RePORTER application 10275504, Vascular Contributions to Cognitive Impairment after Adverse Pregnancy Outcomes: the nuMoM2b-Heart Health Study (1R01NS122815-01). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10275504. Licensed CC0.

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