# Genomic Underpinnings for Breast Cancer Treatments Induced Nausea and Vomiting

> **NIH NIH R01** · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2021 · $127,236

## Abstract

ABSTRACT
This application is in response to the Notice of Special Interest (NOSI) identified as NOT-OD-20-097
titled “Administrative Supplement for Research on the 2019 Novel Corona Virus and the Behavioral
and Social Sciences.” The purpose of this proposal is to add new variables and another year of data
collection to investigate the effect of COVID-19 on the symptom trajectory experienced by women
with breast cancer in their first two years of survivorship, and to identify those women at highest risk
for increased symptom burden. The current longitudinal study focused on the underpinnings of
treatment induced nausea and vomiting, but also the contribution of individual and co-occurring
symptoms including pain, pain interference, sleep disturbance, fatigue, anxiety, depressive
symptoms, physical function, and ability to participate in social roles and activities. The current study
includes collection of these measures on a monthly basis prior to and during the emergence of
COVID-19 for 248 women with breast cancer (with over 100 women over the age of 65 years, making
them a particularly vulnerable group). The planned trajectory analysis of the current study would be
invalid if COVID-19 was not included as a variable. In addition to adding the emergence of COVID-19
to the trajectory analysis, the proposed study will add potential mediators of COVID-19, such as
county of residence in the tri-state area of Western Pennsylvania, resiliency, living arrangements and
job or income loss because of COVID-19. County of residence is important, as the incidence of
COVID-19 in the rural counties was lower and thus the state mandated restrictions were different. In
addition, study participants who lived alone, and who lost their jobs or family income would be
affected differently. Resiliency, the ability to bounce back or adapt when changes occur, may also
influence the impact of COVID-19 on symptoms reported. This supplement, which is within the scope
of the parent award, will strengthen our currently funded aims by use of real-time longitudinal data to
inform key social and behavioral questions related to the COVID-19 pandemic in a vulnerable
population, mostly older women treated for breast cancer.

## Key facts

- **NIH application ID:** 10275659
- **Project number:** 3R01NR016695-03S1
- **Recipient organization:** UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- **Principal Investigator:** Susan Watters Wesmiller
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $127,236
- **Award type:** 3
- **Project period:** 2018-01-22 → 2022-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10275659

## Citation

> US National Institutes of Health, RePORTER application 10275659, Genomic Underpinnings for Breast Cancer Treatments Induced Nausea and Vomiting (3R01NR016695-03S1). Retrieved via AI Analytics 2026-05-28 from https://api.ai-analytics.org/grant/nih/10275659. Licensed CC0.

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