# Proteomic and Functional Analysis of Presynaptic Physiology and Plasticity

> **NIH NIH R01** · DUKE UNIVERSITY · 2021 · $616,145

## Abstract

ABSTRACT
The molecular mechanisms of plasticity within the presynapse and its role in behaviors such as learning and
memory are still poorly understood, mainly due to a lack of knowledge of the signaling molecules of the
presynaptic cytomatrix and tools to spatially and temporally manipulate presynaptic plasticity. This gap in
knowledge is a fundamental barrier to the field. In this project, we will develop and utilize innovative proteomic,
genome editing, and optogenetic approaches to solve these problems, revealing the proteins and inner workings
of the cytomatrix of presynapses from distinct neuronal cell types and their roles in learning and memory. We
anticipate these data will provide a new and unparalleled molecular framework for future studies on presynaptic
physiology as well as insights into how forms of presynaptic plasticity modulate behavior.

## Key facts

- **NIH application ID:** 10276768
- **Project number:** 1R01MH126954-01
- **Recipient organization:** DUKE UNIVERSITY
- **Principal Investigator:** SCOTT H SODERLING
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $616,145
- **Award type:** 1
- **Project period:** 2021-05-10 → 2026-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10276768

## Citation

> US National Institutes of Health, RePORTER application 10276768, Proteomic and Functional Analysis of Presynaptic Physiology and Plasticity (1R01MH126954-01). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10276768. Licensed CC0.

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