Biomedical Informatics, Bioinformatics, Clinical Research and Innovation Hub (BIB-CRI) Summary This proposed alteration/renovation (A&R) component of the Great Plains IDeA Clinical and Translational Research (GP IDeA-CTR) renewal will create the Biomedical Informatics, Bioinformatics, Clinical Research and Innovation Hub (BIB-CRI). This renovation is designed to support the growing needs of biomedical informatics and bioinformatics and interaction space of the GP IDeA-CTR network to meet the GP IDeA-CTR Overall renewal aims: 1) develop the infrastructure, services, resources, and community relationships needed to expand CTR; 2) expand professional development activities to cultivate successful CTR investigators; 3) strengthen collaborative partnerships across GP-IDeA network; and 4) create an environment that fosters innovative multidisciplinary, multisite, and cross-entity (e.g., public-private) partnerships. Accordingly, the A&R specific aims are Aim 1: Renovate a floor of Eppley Science Hall to create the BIB-CRI Hub to expand space for computer-intensive work, Aim 2: Update the infrastructure needed to support computationally-intensive research, including heating, ventilation, and air-conditioning (HVAC), Informational Technology (IT), and building security systems, and Aim 3: Enhance collaborations within and among bioinformatics and CTR teams across the Great Plains-IDeA-CTR, with flexible interaction spaces, such as ‘huddle rooms’, computational team pods, and landing spaces for visiting regional researchers. By building the BIB-CRI hub, we will enhance the ability of the Biomedical Informatics (BIBCE) and the Biostatistics (BERD) Cores to serve informatics and data analytic needs across all GP IDeA-CTR network partners. The renovation of Eppley Science Hall (ESH) 7th floor provides 7,590 net-square-feet of useable space for expanding bioinformatics focused research. This space is centrally located at UNMC and will provide a headquarters for interactions among all GP IDeA-CTR network researchers and clinicians. The BIB- CRI hub will provide updated cyberinfrastructure to support computationally-intensive analyses and high- speed data transfer to off-site supercomputers. Computational pods will provide flexible space to support different team sizes and work-styles. Huddle rooms and other interaction spaces will enhance collaborations, while dedicated work spaces for visiting GP IDeA-CTR faculty and students will increase collaboration and facilitate mentoring and learning. This will increase the dissemination of new tools and approaches for researchers across all GP IDeA-CTR sites. The dedicated BIB-CRI hub built though this renovation will expand the footprint for computational analysis, enhance computational infrastructure and space to engage in professional development activities, strengthen relationships across all GP IDeA-CTR partners, boost collaborative partnerships with the DaCCoTA CTR, reduce duplication of resources, and foster mu...