# CHARACTERIZING AND IMPROVING HUMANIZED IMMUNE SYSTEM MOUSE MODELS (IMM-HIS)

> **NIH NIH N01** · UNIVERSITY OF COLORADO DENVER · 2020 · $2,041,443

## Abstract

This contract proposes to develop, optimize, and test the production of HIS mice using hematopoietic stem cells from cord blood, including the co-transplantation of neonatal thymic tissue.  Comprehensive characterizations of the adaptive and innate human immune systems will include testing its ability to respond to a standard human vaccination and an allograft. The chosen models for optimization and improvement center on increasing populations of innate lymphoid cells which facilitate lymphoid tissue development, that in turn would lead to more robust and complete development of the human immune system.

## Key facts

- **NIH application ID:** 10282227
- **Project number:** 75N93020C00058-0-9999-1
- **Recipient organization:** UNIVERSITY OF COLORADO DENVER
- **Principal Investigator:** JULIE LANG
- **Activity code:** N01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $2,041,443
- **Award type:** —
- **Project period:** 2020-09-30 → 2023-09-29

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10282227

## Citation

> US National Institutes of Health, RePORTER application 10282227, CHARACTERIZING AND IMPROVING HUMANIZED IMMUNE SYSTEM MOUSE MODELS (IMM-HIS) (75N93020C00058-0-9999-1). Retrieved via AI Analytics 2026-05-30 from https://api.ai-analytics.org/grant/nih/10282227. Licensed CC0.

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