# CHARACTERIZING AND IMPROVING HUMANIZED IMMUNE SYSTEM MOUSE MODELS (IMM-HIS)

> **NIH NIH N01** · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2020 · $2,198,719

## Abstract

The study focuses on the ability to substitute MHC-defined porcine fetal thymus tissue for human fetal thymus tissue for the construction of human immune system (HIS) mice. The study explores the ability to substitute MHC-defined porcine fetal thymus tissue for human fetal thymus tissue for the construction of humanized immune system (HIS) mice. T cell reconstitution and function in HIS mice constructed with fetal pig thymic tissue will be compared to mice HIS mice constructed from cord blood CD34+ cells, followed by an attempt to improve reconstitution and function by porcine thymus by using pigs that are transgenic for common HLA alleles.

## Key facts

- **NIH application ID:** 10282228
- **Project number:** 75N93020C00059-0-9999-1
- **Recipient organization:** COLUMBIA UNIVERSITY HEALTH SCIENCES
- **Principal Investigator:** MEGAN SYKES
- **Activity code:** N01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $2,198,719
- **Award type:** —
- **Project period:** 2020-09-30 → 2023-09-29

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10282228

## Citation

> US National Institutes of Health, RePORTER application 10282228, CHARACTERIZING AND IMPROVING HUMANIZED IMMUNE SYSTEM MOUSE MODELS (IMM-HIS) (75N93020C00059-0-9999-1). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10282228. Licensed CC0.

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