# Novel surface-modified bioresorbable zinc-based stent materials

> **NIH NIH R01** · STATE UNIVERSITY NEW YORK STONY BROOK · 2021 · $395,382

## Abstract

Summary: “Zinc-Aβ interaction and its toxicity on brain cells”
Zinc is essential for health and is the second abundant trace element in human brain. Zinc dyshomeostasis is
implicated in the elderly population and Alzheimer’s disease (AD) which has many other risk factors besides Aβ
and tau. Emerging evidence demonstrated that zinc also plays an important role in the pathogenesis of AD such
as Aβ production and aggregation, tau phosphorylation, redox homeostasis, and brain-derived neurotrophic
factor (BDNF) signaling. Zinc dyshomeostasis could be a therapeutic target for AD treatment. However, there
are still controversies on the zinc concentration alteration, and the effect of zinc overload or zinc deficiency in
AD patients, mouse models and cell lines. Providing these significant discrepancies across reported studies,
more carefully-designed cellular, preclinical and clinical investigations are needed to portray a clearer picture of
zinc’s role in AD development before clinical applications. Toward this end, we aim to investigate the interactions
between zinc and Aβ, effect of zinc binding on Aβ aggregation, and the potential toxicity of Zn-chelated Aβ (ZnAβ)
species on a variety of brain cells including neurons, microglia, astrocytes, and cerebrovascular cells in this one-
year supplemental project.

## Key facts

- **NIH application ID:** 10282711
- **Project number:** 3R01HL140562-04S1
- **Recipient organization:** STATE UNIVERSITY NEW YORK STONY BROOK
- **Principal Investigator:** Yadong Wang
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $395,382
- **Award type:** 3
- **Project period:** 2018-06-01 → 2023-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10282711

## Citation

> US National Institutes of Health, RePORTER application 10282711, Novel surface-modified bioresorbable zinc-based stent materials (3R01HL140562-04S1). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10282711. Licensed CC0.

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