# Characterizing the Regulation of Ferroptosis

> **NIH NIH R01** · STANFORD UNIVERSITY · 2021 · $84,185

## Abstract

Project Abstract
Ferroptosis is an iron-dependent, oxidative cell death pathway implicated in tumor suppression
and pathological cell death. This process is biochemically distinct from apoptosis, classic
necrosis and iron overload-induced cell death. How ferroptosis is regulated at the molecular
level is poorly understood. Guided by preliminary data, this research will test the hypotheses
that ferroptosis is regulated by mechanistic target of rapamycin (mTOR) signaling and neutral
lipid synthesis. Moreover, imaging studies using existing and newly discovered antioxidant
inhibitors of ferroptosis will pinpoint the cellular sites of lethal iron-dependent lipid reactive
oxygen species (ROS) accumulation during ferroptosis and examine how this accumulation is
affected by mTOR signaling and neutral lipid synthesis. These studies will be performed in
human cells with the aid of a novel time-lapse cell death imaging system and techniques drawn
from chemical biology, genetics and biochemistry. This research will advance the understanding
of ferroptosis at the molecular and cellular levels and lay the foundation for future in vivo studies
of this poorly understood cell death process.

## Key facts

- **NIH application ID:** 10283636
- **Project number:** 3R01GM122923-04S1
- **Recipient organization:** STANFORD UNIVERSITY
- **Principal Investigator:** Scott Dixon
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $84,185
- **Award type:** 3
- **Project period:** 2017-09-05 → 2022-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10283636

## Citation

> US National Institutes of Health, RePORTER application 10283636, Characterizing the Regulation of Ferroptosis (3R01GM122923-04S1). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10283636. Licensed CC0.

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