# Age-related hearing deficits in noise-exposed mouse models of Alzheimer's Disease

> **NIH NIH R01** · STATE UNIVERSITY OF NEW YORK AT BUFFALO · 2021 · $287,004

## Abstract

Summary
It is well known that Alzheimer's disease (AD) and hearing loss often occur together. What is unknown,
however, is the relationship between noise exposures and patients with AD. Our goal with this supplement is
to examine the link between noise exposure, age, listening environment (noise or quiet), and sex in transgenic
mouse models of AD compared to wild-type mice. In our one Specific Aim, we will behaviorally measure
auditory acuity before and after noise exposures in the above groups of mice and the two listening
environments to determine if young AD mutants are more susceptible to noise exposure than young wild-type
mice, and to examine the differences of the susceptibility to noise in quiet and noise environments. In our
parent grant, we have been measuring the effects of noise on hearing in young and old, male and female
mice, and have found that old mice suffer greater hearing loss post-noise exposure than young mice when
listening in quiet environments, but not in noisy environments. This supplement will utilize the same
techniques in two mouse models of AD to determine if young AD mice act like old wild-type mice in terms of
susceptibility to hearing loss following acoustic trauma. Although these mouse models are commonly used to
study the anatomical correlates of AD, we are only beginning to comprehend the functional implications of AD
on hearing, especially hearing in noise, and these experiments will help us better understand how aging, sex,
and noise all play a role in the communication problems faced by patients with AD.

## Key facts

- **NIH application ID:** 10284502
- **Project number:** 3R01DC016641-03S1
- **Recipient organization:** STATE UNIVERSITY OF NEW YORK AT BUFFALO
- **Principal Investigator:** MICHEAL L DENT
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $287,004
- **Award type:** 3
- **Project period:** 2018-05-01 → 2023-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10284502

## Citation

> US National Institutes of Health, RePORTER application 10284502, Age-related hearing deficits in noise-exposed mouse models of Alzheimer's Disease (3R01DC016641-03S1). Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/grant/nih/10284502. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*