# NIH BLUEPRINT NEUROTHERAPEUTICS NETWORK (BPN) MEDICINAL CHEMISTRY SUPPORT PROGRAM (MCSP)

> **NIH NIH N01** · ALBANY MOLECULAR RESEARCH, INC. · 2020 · $270,145

## Abstract

The National Institute on Neurological Disorders and Stroke (NINDS) and the NIH Blueprint
Neurotherapeutics Network (BPN) http://neuroscienceblueprint.nih.gov/bpdrugs/index.htm have a need
for the Medicinal Chemistry Support Program (MCSP) to provide a full-service facility and staff who would
support a medicinal chemistry program in the late Lead Optimization phase to provide in vitro absorption,
distribution, metabolism, excretion and toxicology (ADMET) support to characterize top lead candidates to
determine best preclinical candidate and to provide compound logistics of storage and shipping to support
the Contributor (Dingledine, Emory University) to develop a novel therapeutic effective in cognitive
deficits/epilepsy. This will be achieved by advancing the SPR of their small molecule heterocyclic starting
compound utilizing in vitro ADMET to identify novel to differentiate top lead compounds. Candidate
molecules have undergone some profiling related to the physicochemical properties and biological
activity. The goal is to advance the project to go/no go decision amongst the top compounds provided by
the Contributor. The data generated from this contract will be used by NINDS, contributors or sponsored
investigators in support of Investigational New Drug (IND) application directed preclinical activities. The
results of the efforts of this contract will be the basis to advance preclinical candidate compounds for
further development i.e., advanced PK and toxicological evaluation in preparation of IND filings.

## Key facts

- **NIH application ID:** 10285340
- **Project number:** 271201800001I-0-759502000001-1
- **Recipient organization:** ALBANY MOLECULAR RESEARCH, INC.
- **Principal Investigator:** KEITH BARNES
- **Activity code:** N01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $270,145
- **Award type:** —
- **Project period:** 2020-02-24 → 2021-02-23

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10285340

## Citation

> US National Institutes of Health, RePORTER application 10285340, NIH BLUEPRINT NEUROTHERAPEUTICS NETWORK (BPN) MEDICINAL CHEMISTRY SUPPORT PROGRAM (MCSP) (271201800001I-0-759502000001-1). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10285340. Licensed CC0.

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