# Midwest TXTXT: Scale up of an Evidence-Based Intervention to Promote HIV Medication Adherence

> **NIH ALLCDC U01** · LURIE CHILDREN'S HOSPITAL OF CHICAGO · 2021 · $350,000

## Abstract

PROJECT SUMMARY ABSTRACT
In this application, we propose to scale up an Evidence-Based Intervention- TXTXT- by creating a regional hub
in the Midwest to coordinate broad dissemination, and to greatly increase reach and impact. We will evaluate
the implementation of the EBI scale up via a hybrid type II design to inform the broad dissemination of a
region-based implementation model and will elaborate a sustainability plan for TXTXT to inform wide scale
dissemination and rapid scale up to additional US regions.
Specific Aims:
 1. Determine the real-world efficacy of a regional scale up of an EBI- TXTXT- on our primary and
 secondary outcomes: adherence, viral load suppression, and retention in HIV care, respectively, among
 poorly adherent racial/ethnic minority YLH, ages 16-35 at 3-and 6-month follow-up.
 2. Apply the Consolidated Framework for Implementation Research (CFIR) to describe the implementation
 process and identify barriers and facilitators needed to be addressed; and measure implementation
 outcomes of the TXTXT intervention using the RE-AIM framework (Reach, Efficacy, Adoption,
 Implementation, Maintenance).
Dr. Johnson is an ideal candidate for an HIV-focused Implementation Science mentorship award. She is a
trained Infectious Disease Epidemiologist with initial certification in Implementation Science approaches and
methods (not yet applied). As an early career HIV prevention scientist, she has a breath of experience that
stems from community-engaged research which includes basic science, including surveillance and
epidemiology as well as intervention development and capacity development initiatives. The next logical step is
to gain skills in systems-level implementation science and sustainability planning to inform broad dissemination
of evidence-based interventions. This study combines behavioral and social science, implementation science,
and information dissemination towards the ultimate goal of public health impact. Medication adherence is a key
driver of viral suppression and this regional TXTXT initiative, with a longer-term objective of national
dissemination and focused on patients at most risk of virologic failure will directly address local, regional and
national goals to End the Epidemic by 2030.

## Key facts

- **NIH application ID:** 10285610
- **Project number:** 1U01PS005214-01
- **Recipient organization:** LURIE CHILDREN'S HOSPITAL OF CHICAGO
- **Principal Investigator:** Amy Kristen Johnson
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** ALLCDC
- **Fiscal year:** 2021
- **Award amount:** $350,000
- **Award type:** 1
- **Project period:** 2021-06-01 → 2024-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10285610

## Citation

> US National Institutes of Health, RePORTER application 10285610, Midwest TXTXT: Scale up of an Evidence-Based Intervention to Promote HIV Medication Adherence (1U01PS005214-01). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10285610. Licensed CC0.

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