ABSTRACT: ADMINISTRATIVE CORE The Administrative Core of our Liver Cancer in American Indians and Alaska Natives and Disparities (Li-CAD) P20 program will serve to optimize the work of discovery conducted by the P20 Projects and Cores through administrative support, enhancement of communication, data dissemination and structured oversight. The Administrative Core will provide guidance and enhance communication for and between the following groups: • Li-CAD Executive Committee • Li-CAD External and Internal Advisory Boards • Participating Institutions (University of Washington [UW]; Fred Hutchinson Cancer Research Center [FHCRC]; Alaska Native Tribal Health Consortium [ANTHC]; Cherokee Nation Health Service [CNHS]; University of Texas Southwestern [UTSW]; Kumamoto University, Japan) • AI/AN Leadership Council (ANTHC and CNHS) • Discovery Team (Research Projects; Developmental Research Program; Biorepository; Biostatistics) • Education and Advocacy Team (AI/AN Advocacy Committee, Education and Conference Committee; Career Enhancement Program) • National Institutes of Health (NIH) and National Cancer Institute (NCI) representatives The Li-CAD P20 is comprised of a unique collaboration of multiple entities (Figure 1). Investigators from each entity have demonstrated prior success in collaborative research and will partner in this program to establish the infrastructure to develop a highly innovative, productive and significant program of discovery whose aim it is to reduce disparities in liver cancer outcomes among Alaska Native and American Indian people. The Core has the following Specific Aims: Specific Aim 1: To provide the organizational structure for supporting the key objectives of the Li-CAD P20 and to promote AI/AN-appropriate research objectives, community involvement and dissemination of findings Specific Aim 2: To integrate the Li-CAD P20 with the host institutions (UW, FHCRC, ANTHC, CNHS and UTSW) and AI/AN Tribal and Research organizations at ANTHC and CNHS. Specific Aim 3: To provide oversight for the Li-CAD P20 Program Research Projects and Cores through structured and transparent evaluation of all P20 Program activities and prepare the transition to P50 SPORE.