# Leveraging mHealth to deliver integrated pain-CBT, opioid monitoring, and self-management support for advanced cancer patients coping with chronic pain

> **NIH NIH R21** · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · 2022 · $221,568

## Abstract

Project Summary
Pain affects approximately two thirds of patients with advanced cancer, with rates approaching 90% near the
end-of-life. Although pharmacotherapy is vitally important to alleviating chronic cancer pain, psychological
factors also substantially influence pain outcomes. Cognitive Behavioral Therapy for pain (pain-CBT) is
effective for chronic cancer and non-malignant pain. Unfortunately, pain-CBT in its traditional format (60-
minute, in-person sessions for 12-16 weeks) is unrealistic for advanced cancer patients. Effective
biopsychosocial cancer pain management requires substantial adaptation to meet the real-life needs of
advanced cancer patients and should ideally integrate with pharmacotherapy support. Given the expansive
need, mobile health technology is a promising strategy to deliver and ultimately disseminate brief, pain-CBT
interventions to cancer patients.
Our goal is to improve advanced cancer patients' pain self-management by adapting and integrating pain-CBT
into our existing mHealth program designed to support patients' pharmacologic management. Our parent
intervention, STAMP (Smartphone Technology to Alleviate Malignant Pain) is a patient-facing smartphone
application that supports daily symptom and opioid monitoring, and delivers tailored pain psychoeducation and
advice. We have a strategic opportunity to adapt and integrate pain-CBT to create novel mHealth intervention
that harmonizes psychological and medical support for advanced cancer pain. Leveraging mobile technology,
we will simulate the therapeutic experience of pain-CBT by 1) presenting advanced cancer-specific, multimedia
psychoeducational content, 2) developing schedules to deliver daily, brief didactics, 3) facilitating insight
building via surveys and tailored feedback, & 4) stimulating active learning through gamified cognitive
restructuring exercises and audio-recorded relaxations. In Aim 1: We will supplement our multi-media library of
cancer pain psycho-education and adapt pain-CBT content for brief mHealth delivery specific to advanced
cancer, while integrating clinician and patient (n=20) feedback throughout. In Aim 2: 25 patients with chronic
pain from advanced cancer will use STAMP+CBT for 6 weeks. Findings will illuminate feasibility of app use
and data collection for a larger future efficacy trial (R01), allowing for exploration of meaningful trends in pain,
psychological mediators, and care utilization. If proven effective, this pain-CBT and opioid management
intervention has great potential to scale and make biopsychosocial pain treatment available to a population that
suffers disproportionately from chronic pain and has little access to non-pharmacologic pain management
treatments.

## Key facts

- **NIH application ID:** 10286805
- **Project number:** 1R21CA263838-01
- **Recipient organization:** UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
- **Principal Investigator:** Desiree R Hilton
- **Activity code:** R21 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $221,568
- **Award type:** 1
- **Project period:** 2022-05-01 → 2024-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10286805

## Citation

> US National Institutes of Health, RePORTER application 10286805, Leveraging mHealth to deliver integrated pain-CBT, opioid monitoring, and self-management support for advanced cancer patients coping with chronic pain (1R21CA263838-01). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10286805. Licensed CC0.

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