# Center for Aging and Policy Studies - Alzheimer's Disease Research Supplement

> **NIH NIH P30** · SYRACUSE UNIVERSITY · 2021 · $221,721

## Abstract

The proposed research consists of five distinct Pilot Projects, each of which will be carried out as
part of the Center for Aging and Policy Studies (CAPS)’s Program Development (Pilot) Core (Core
B). All five are population-based social science studies that address one or more of NIA’s
announced priorities in the area of Alzheimer’s disease and related dementias (ADRD)
research. Two of the proposed tasks represent a broadening of the analyses conducted in existing
Pilot Projects. (1) Consequences of Disabilities in Late Middle Age for Consumption Well-
Being, will examine the consequences of disability in late middle age for economic well-being
using consumption-based measures instead of the usual income-based measures. (2) Health
Shocks and Changes in Spatial Proximity between Parents and Children will study how
changes in spatial proximity of family members evolves relative to changes in health, such as an
AD diagnosis. The remaining three projects represent new, ADRD-focused studies that contribute
to CAPS’s Specific Aims. (3) Estimated Arterial Stiffness as a Predictor of Cognitive Decline
and Dementia in Middle-Aged and Older Adults will use a novel survey-based measure of
arterial stiffness to predict cognitive decline and the transition to a dementia diagnosis. (4)
Comparing Alzheimer’s Related Mortality Among People with and without Down Syndrome
examines differences between those with and without Down syndrome with respect to ADRD
prevalence and in reported cause of death. (5) Living alone and risk for the development of
Alzheimer’s Disease and related dementias: When does solitary living matter and why will
investigate the role of living alone as a risk factor for ADRD onset, as well as the presence of
factors that buffer this risk. Together, these projects will produce important new findings in a
number of priority areas, including the proposed research will address both the prevalence and
the incidence of cognitive decline and dementia; will inform the knowledge base with respect to
trajectories of cognitive decline and aging; and will provide new findings on the consequences
for individuals and their families of prevalent ADRD, adding to our knowledge about the
population-level burden of illness. Additionally, one of the proposed projects will develop and
apply an innovative approach to using biomarkers as an early sign of dementia, which promises
to add to our knowledge regarding causal pathways to cognitive decline and ADRD, and to
suggest possible malleable mechanistic targets on behavioral and social pathways to ADRD.

## Key facts

- **NIH application ID:** 10286938
- **Project number:** 3P30AG066583-01S1
- **Recipient organization:** SYRACUSE UNIVERSITY
- **Principal Investigator:** Jennifer Karas Montez
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $221,721
- **Award type:** 3
- **Project period:** 2020-07-15 → 2025-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10286938

## Citation

> US National Institutes of Health, RePORTER application 10286938, Center for Aging and Policy Studies - Alzheimer's Disease Research Supplement (3P30AG066583-01S1). Retrieved via AI Analytics 2026-06-12 from https://api.ai-analytics.org/grant/nih/10286938. Licensed CC0.

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