# Development of a novel method for cannulation in pediatric cardiac procedures

> **NIH NIH R21** · CHILDREN'S RESEARCH INSTITUTE · 2021 · $238,298

## Abstract

Project Summary
 The goal of this proposal is to develop a quick-connect cannulation system to allow rapid, easy, and safe
cannulation in pediatric cardiac patients. Extracorporeal membrane oxygenation (ECMO) has emerged as a
vital tool for saving patients suffering cardiovascular and/or respiratory failure. However, even in well
experienced hands, the initiation of ECMO support is relatively time consuming in a stressful environment with
frequent complications.
 The goal of this R21 proposal submission is to develop a novel quick-connection cannulation system to
allow for rapid, easy, and safe cannulation in the pediatric population. This proposal is being submitted to PA-
18-482 after discussion with NICHD program officers. We will accomplish this through two specific aims.
 Aim 1: Develop new rapid cannulation device. A new rapid cannulation device will be developed and
prototyped. The device will be designed to securely attach to current commercial arterial and venous cannulas
from 8Fr-16Fr in diameter and tested for mechanical stability on a tensile testing machine.
 Aim 2: Evaluate device in bench top and swine animal tests. The device will first be evaluated in a bench
test using 3D printed model hearts and a closed loop pressurized system to mimic cardiac flow. Once these
tests are successful, swine animal trials will be done using expired pigs from other research projects at our
institute.
 The successful completion of this project will provide us with a prototype device that can move towards
clinical studies in future work, which would include developing a biodegradable version. An alternative safe,
easy, and fast cannulation procedure may reduce the duration of E-CPR by minimizing the time needed for
secure cannulation, reducing or even preventing potential damage to the brain and other organ systems. Such
an innovation has the potential to significantly improve outcomes both in terms of mortality and morbidity of
pediatric patients undergoing E-CPR.

## Key facts

- **NIH application ID:** 10286952
- **Project number:** 1R21HD105965-01
- **Recipient organization:** CHILDREN'S RESEARCH INSTITUTE
- **Principal Investigator:** Can Yerebakan
- **Activity code:** R21 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $238,298
- **Award type:** 1
- **Project period:** 2021-08-06 → 2023-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10286952

## Citation

> US National Institutes of Health, RePORTER application 10286952, Development of a novel method for cannulation in pediatric cardiac procedures (1R21HD105965-01). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10286952. Licensed CC0.

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