# Network on Life Course Health Dynamics and Disparities in 21st Century America

> **NIH NIH R24** · SYRACUSE UNIVERSITY · 2021 · $409,194

## Abstract

The proposed supplement consists of five innovative pilot projects to be added to the R24 Network
on Life Course Health Dynamics and Disparities in 21st Century America (NLCHDD). All five
projects are population-based social science research that address NIA’s announced priorities in
the area of Alzheimer’s disease and related dementias (ADRD) research. In addition, all five
directly advance the overarching objective and specific aims of the parent grant. The overarching
objective of the NLCHDD is to create a network of emerging, established, and underrepresented
life course and aging researchers across multiple disciplines to generate new evidence and
disseminate data and analytic resources to better understand the worrisome trends and
disparities in U.S. adult health and longevity across the life course and in geographic context. To
achieve this objective, the NLCHDD stimulates innovative and interdisciplinary research to
generate this evidence through multiple activities, including supporting innovative pilot projects.
The five proposed supplemental pilot projects are: (1) Education, Psychological Resilience,
and Cognitive Decline in Later Life will examine the potential role that psychological resilience
plays in mediating and mitigating the association between educational attainment and cognitive
decline, (2) Neighborhood Adversity and Cognitive Decline and Dementia Among US Older
Adults will examine how long-term exposure to neighborhood adversity impacts cognitive decline
and dementia in older ages, and how physiological dysregulation may mediate the association
and how psychosocial resources could mitigate the association, (3) Alzheimer’s Disease and
Related Dementias across the Rural-Urban Continuum will examine how ADRD develops over
time and across the urban-rural continuum, and how these patterns differ across region of
residence and subgroups defined by gender, race/ethnicity, and education, (4) Effects of Air-
based Chemical Toxicants on Cognitive Function and Impairment Among Older Adults will
link estimates of exposure to chemical air pollutants to respondents in the HRS HCAP subsample
and investigate the synergistic effects of exposure to air pollution and social stressors on
race/ethnic disparities in cognitive functioning, and (5) Fitting the Geographic Distribution of
Alzheimer’s Disease and Related Dementias to Administrative Divisions for Health Policy
Effectiveness: A Modifiable Areal Unit Problem Approach will integrate data from multiple
sources to estimate variation in ADRD across various levels of geography to understand how
different spatial units may obscure accurate representation of geographic variation in ADRD.
These projects will produce important findings about the development of and disparities in ADRD.

## Key facts

- **NIH application ID:** 10288522
- **Project number:** 3R24AG045061-07S1
- **Recipient organization:** SYRACUSE UNIVERSITY
- **Principal Investigator:** JENNIFER A AILSHIRE
- **Activity code:** R24 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $409,194
- **Award type:** 3
- **Project period:** 2014-09-30 → 2024-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10288522

## Citation

> US National Institutes of Health, RePORTER application 10288522, Network on Life Course Health Dynamics and Disparities in 21st Century America (3R24AG045061-07S1). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10288522. Licensed CC0.

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