# Information Processing in Auditory Cortex

> **NIH NIH R01** · JOHNS HOPKINS UNIVERSITY · 2021 · $407,421

## Abstract

Adults with hearing loss have a higher risk for Alzheimer’s and other cognitive disorders. Individuals
with moderate to severe hearing loss are up to five times more likely to develop Alzheimer's disease and
dementia, compared to those with normal hearing. Nonhuman primates (NHP) are crucial animal models for
research on Alzheimer's disease and its related dementias because of their close evolutionary relationship to
humans, with whom they share similar anatomy, physiology, and genetic interactions. The common marmoset
(Callithrix jacchus) is a NHP model of increasing importance for aging research. This new world primate
provides some unique advantages for the study of aging and aging-related disorders, including its relatively
short lifespan among all the NHP used in biomedical research. Marmosets also show patterns of age-related
hearing loss similar to humans and are known to develop amyloidosis, a major biological marker for
Alzheimer’s disease, naturally at old age. Amyloidosis is also transmissible to this species, making it an
extremely promising NHP model for Alzheimer’s disease. The goal of this administrative supplement
application is to fill in gaps in our knowledge of auditory processing by aging marmosets. Such knowledge will
be extremely valuable to the scientific community studying Alzheimer's disease and its related dementias. Our
laboratory is a leader in marmoset neuroscience research and has pioneered many behavioral and
physiological techniques for marmoset studies. We plan to take the advantage of this unique model system in
response to NIH RFA NOT-AG-20-034. The proposed aims are within the scope of the parent R01 award
(DC003180) and this RFA.

## Key facts

- **NIH application ID:** 10289000
- **Project number:** 3R01DC003180-25S1
- **Recipient organization:** JOHNS HOPKINS UNIVERSITY
- **Principal Investigator:** XIAOQIN WANG
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $407,421
- **Award type:** 3
- **Project period:** 1997-01-01 → 2025-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10289000

## Citation

> US National Institutes of Health, RePORTER application 10289000, Information Processing in Auditory Cortex (3R01DC003180-25S1). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10289000. Licensed CC0.

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