Project Summary – Administrative Core (Core A) The proposed research program will investigate outcome disparities in Latino children and adolescents with acute lymphoblastic leukemia (ALL). The Program is built on a multi-institutional consortium, the Reducing Ethnic Disparities in Acute Leukemia (REDIAL) Consortium, comprising 6 pediatric cancer centers in the southwestern United States, with large proportions of Latino children and adolescents with acute lymphoblastic leukemia (ALL). Core A, the Administrative Core, will oversee and coordinate all entities of the Program Project to ensure maximal synergy of the Cores, Projects, and the Developmental Research Program (DRP). This Program includes: Core B, the Biospecimen Processing and Storage Core; Core C, the Biostatistics and Data Management Core; Project 1, investigating etiology and impact of ethnic disparities in therapy-associated hepatotoxicity; Project 2, investigating ethnic disparities in methotrexate neurotoxicity; and a DRP, to support the development of innovative pilot projects. By facilitating employment, training, regulatory compliance, internal and external communication, and financial management of the Program Project, Core A will maximize the productivity and efficiency of all participating Projects and Cores. Under the leadership of Co-Directors Drs. Karen Rabin and Philip Lupo, Core A will be responsible for overseeing the conduct of the research at the various sites, including the regulatory, financial, and human resources aspects. Core A will also ensure regular internal communication among investigators and sites and organize external communication with leaders in the field, the scientific community, and patient advocacy organizations. Core A will (1) oversee all human resource management responsibilities, including creation of job descriptions and the hire, evaluation, and replacement of personnel locally and at the Consortium sites; (2) provide regulatory management and governance to the Program Project, including tracking regulatory submissions/approvals and assisting with necessary training of research staff; (3) control expenditures and maintain budget information for all Projects, Cores, and Consortium sites; and (4) facilitate internal and external communication among all participating Project Leaders, Core Directors, and sites through regular meetings to ensure adequate enrollment rates, identify and solve logistical issues, and present updates on the progress of the research. An Internal Advisory Board (IAB) and External Advisory Board (EAB) will be established, both of which will include leaders in the fields of pediatric leukemia biology, genomics, epidemiology, supportive care, and patient advocacy, including two leaders of funded Specialized Programs of Research Excellence (SPOREs). There will be twice yearly meetings of the IAB and an annual virtual meeting of the EAB, during which the Project Leaders and Core Directors will present results for feedback and ...