PROJECT SUMMARY – Biostatistics and Data Management Core (Core C) The translational Research Projects proposed in this P20 planning grant integrate many different types of existing and newly generated data, including biological, clinical, demographic, genomic, metabolomic, imaging, and neighborhood variables. The Biostatistics and Data Management Core (Core C) functions as a centralized research design and data science coordination center for all P20 Projects, bringing together expertise and intellectual resources in biostatistics, bioinformatics, geospatial data analysis, and data management for all P20 investigators. Core C will provide the statistical and data science infrastructure needed for development of a future SPORE application upon completion of the P20 planning grant. Core C members will: 1) provide biostatistical and bioinformatics support for rigorous research design and state-of-the-science statistical analysis for all P20 Projects and the Developmental Research Program (DRP); 2) facilitate state-of-the-science geospatial data analysis for all P20 Projects and the DRP; and 3) develop and maintain an integrated database environment for efficient data management, integration, analysis and sharing for all P20 Projects, the DRP and investigator-initiated inquiries. Core C members will work collaboratively with investigators to ensure that the appropriate design is incorporated into all studies from inception, that data are appropriately validated, linked, cleaned and analyzed, and that all results will be interpreted for statistical as well as biological/clinical significance. The Biostatistics and Data Management Core will work with the Administrative Core (Core A) to assist in preparation of reports, data management and other administrative duties; and with the Biospecimen Processing and Storage Core (Core B) for management and analysis of specimen-related data. Fully integrating Core C members into all P20 Projects and other Cores will build workflow efficiencies and support the translational goals of the P20, while enhancing quality and ensuring scientific integrity of participating Projects. Core C will provide sophisticated data management, design, and analysis services in order to facilitate important discoveries about acute lymphoblastic leukemia ethnic disparities and to guide future prevention and intervention strategies.