# Examining the Longitudinal Influence of the Physical and Social Environments on Social Isolation and Cognitive Health: contextualizing the role of technology

> **NIH NIH F99** · UNIVERSITY OF SOUTHERN CALIFORNIA · 2021 · $41,136

## Abstract

PROJECT SUMMARY
 Social wellbeing and cognitive health are two pillars of successful aging, and they are interrelated. Three
decades of research have consistently shown that social isolation is associated with declines in cognitive
functioning. Although existing literature has explored the individual-level risk and protective factors, researchers'
attention has been less paid to the extent to which physical and social characteristics of the living environment
affect social isolation and cognitive health. The Ecological Theory of Aging (ETA) posits environmental factors
have significant influences on health and social wellbeing. Negative physical characteristics of the environment
were hypothesized to be related to increased social isolation and cognitive decline longitudinally. An increasing
amount of research investigated the association between ICT use and social isolation, yet whether ICT use
would interact with the effect of environmental factors on the risk of social isolation has not yet been empirically
tested. Besides, the influence of ICT use on cognitive health has not been well understood. Promoting social
interaction using technology-based approaches have the potential to alleviate social isolation among older
people and prevent cognitive decline. The proposed dissertation work (F99) will examine the effect of physical
and social environments of living on social isolation and cognitive health. The effects of ICT use will be
investigated within living contexts. Multi-level modeling and structural equation modeling methods will be
employed to conduct secondary data analysis using data from the National Health & Aging Trend Study (NHATS)
wave 5 to 9. The postdoctoral stage (K00) is guided by the overarching aim of building knowledge on the
behavioral and contextual pathways that could explain the association between social isolation and cognitive
decline and developing a community-based behavioral health intervention. At the K00 phase, the PI will increase
understanding of the social isolation and cognitive health research landscape by conducting a systematic review.
Longitudinal data from the ongoing Internet-based Conversational Engagement Clinical Trial (I-CONECT) will be
analyzed to examine the association between social isolation and change in neuropsychological outcomes. The
PI will utilize the longitudinal data collected with the Collaborative Aging Research Using Technology (CART)
platform to investigate the relationships between daily activities, social engagement, and the cognitive health of
older participants. Knowledge to be built at F99 and K00 stages will be synthesized to inform the participatory
co-design of a technology-facilitated intervention program for social isolation and cognitive decline. The proposed
research will produce knowledge on the influence of environmental factors on social isolation and cognitive
health, and achieve the PI’s long-term professional goal of developing behavioral health intervention to add...

## Key facts

- **NIH application ID:** 10291360
- **Project number:** 1F99AG068492-01A1
- **Recipient organization:** UNIVERSITY OF SOUTHERN CALIFORNIA
- **Principal Investigator:** Kexin Yu
- **Activity code:** F99 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $41,136
- **Award type:** 1
- **Project period:** 2021-09-15 → 2022-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10291360

## Citation

> US National Institutes of Health, RePORTER application 10291360, Examining the Longitudinal Influence of the Physical and Social Environments on Social Isolation and Cognitive Health: contextualizing the role of technology (1F99AG068492-01A1). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10291360. Licensed CC0.

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