# Cancer Center Support Grant

> **NIH NIH P30** · DUKE UNIVERSITY · 2021 · $123,589

## Abstract

The HIV/AIDS epidemic remains a significant public health problem, affecting more than 36 million
people worldwide. Plasmablastic lymphoma is an AIDS-defining malignancy and among the most
lethal cancers affecting HIV-infected patients who account for over two-thirds of the cases worldwide
(1 ). Plasmablastic lymphoma is a particularly lethal disease with a median survival of 6-9 months. The
central goal of this proposal is to conduct a well-powered genomic study of plasmablastic lymphoma
that serves as a lasting resource for defining the biology of this disease.
In spite of the poor outcomes associated with plasmablastic lymphoma, their genomic landscape
remains mostly unknown. Defining the genetic landscape of plasmablastic lymphoma in both HIV
positive and negative cases would allow us to identify specific features of plasmablastic lymphoma
that emerge from the interactions between HIV infection and genetic factors underlying
lymphomagenesis. We have enrolled a large cohort of plasmablastic lymphoma patients (N=148) that
comprise both HIV positive (N=108) and HIV-negative (N=40)
Aim 1. Comprehensively define the genomic profiles of plasmablastic lymphomas
In this aim, we propose to define the genetic alterations and gene expression profiles of
plasmablastic lymphomas using whole exome sequencing and RNA sequencing and compare them
to HIV-negative cases.
Aim 2: Define the role of the microenvironment in plasmablastic lymphomas
In this aim, we propose to define the composition of the tumor microenvironment in plasmablastic
lymphomas using single cell sequencing.

## Key facts

- **NIH application ID:** 10292720
- **Project number:** 3P30CA014236-47S1
- **Recipient organization:** DUKE UNIVERSITY
- **Principal Investigator:** Michael B Kastan
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $123,589
- **Award type:** 3
- **Project period:** 1997-01-01 → 2024-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10292720

## Citation

> US National Institutes of Health, RePORTER application 10292720, Cancer Center Support Grant (3P30CA014236-47S1). Retrieved via AI Analytics 2026-06-01 from https://api.ai-analytics.org/grant/nih/10292720. Licensed CC0.

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