# Comprehensive imaging and quantification of blood flow for investigating ocular diseases without additional contrast agent

> **NIH NIH R44** · PHYSICAL SCIENCES, INC · 2021 · $678,314

## Abstract

Project Summary/Abstract
 Physical Sciences Inc. (PSI) in collaboration with New York University (NYU) School of Medicine
proposes to develop a novel ophthalmic imaging platform for characterizing retinal morphology and
monitoring ocular blood flow abnormalities. This platform will combine non-invasive measurements of
retina/choroid structure and ocular blood flow based on optical coherence tomography (OCT) and wide-
field semi-quantitative global flow visualization using line-scanning Doppler flowmetry (LSDF). The
combination of these two imaging modalities within the same imaging platform enables comprehensive
assessment of blood flow in the retina and choroid. This novel imaging platform will enable imaging
studies in animals and human subjects with normal vision or with various retinal diseases. Prior PSI
experience in developing advanced ophthalmic imaging systems coupled with our collaborators' expertise
in Ophthalmology will be leveraged to ensure the successful outcome of this important R&D program.
 A feasibility study will be performed during the Phase I program by imaging normal and diseased rodent
models using a benchtop instrument. A clinical prototype instrument will be manufactured and tested
clinically in Phase II in the NYU population of patients to highlight hemodynamic retinal biomarkers. We
choose to focus on diseases that are the leading causes of blindness including, age-related macular
degeneration (AMD), diabetic retinopathy (DR), and glaucoma to demonstrate the clinical utility of our novel
system. We will recruit healthy individuals to set a reference, and subjects with AMD, DR, and glaucoma at
a wide range of disease severity. In all of these conditions, the ability to record in vivo blood flow will
provide novel information that will open new diagnostic and treatment avenues.

## Key facts

- **NIH application ID:** 10295545
- **Project number:** 4R44EY030812-02
- **Recipient organization:** PHYSICAL SCIENCES, INC
- **Principal Investigator:** Mircea Mujat
- **Activity code:** R44 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $678,314
- **Award type:** 4N
- **Project period:** 2019-09-01 → 2023-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10295545

## Citation

> US National Institutes of Health, RePORTER application 10295545, Comprehensive imaging and quantification of blood flow for investigating ocular diseases without additional contrast agent (4R44EY030812-02). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10295545. Licensed CC0.

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