# Clinical and Translational Science Award

> **NIH NIH UL1** · MEDICAL COLLEGE OF WISCONSIN · 2021 · $1,731,898

## Abstract

PROJECT SUMMARY
The proposed administrative supplement to the CTSA award at the Clinical and Translational Science Institute
(CTSI) of Southeastern Wisconsin is a randomized blinded placebo-controlled trial to evaluate the efficacy of
treatment with convalescent plasma (CP) in hospitalized patients with COVID-19. Studies have shown that CP
is safe for transfusion in COVID-19 patients. However, this trial was developed to obtain scientific evidence to
support or reject the hypothesis that CP may be a therapeutic option for COVID-19. The hypothesis underpinning
this trial is that compared to placebo, administration of CP will avert respiratory deterioration, the main cause of
death, and improve clinical status in patients hospitalized with COVID-19. This trial is being conducted across
several sites that have experienced rapidly rising numbers of COVID-19 cases, including Miami, Florida, New
York City, New York, and Houston Texas. Wisconsin is the new epicenter of the COVID-19 pandemic in the
United States, and one of the global hot spots. This study is within the scope of the existing CTSA award, with
its focus on network trials and rapid site initiation and team science, and leverages the CTSI's focus on mobilizing
resources in response to rapidly emerging infectious diseases. Wisconsin will serve as a new site in this quickly
designed and launched trial, building upon the work already done in NYC to develop a multicenter, well-powered
trial via regional collaborations and CTSA consortium partnerships.

## Key facts

- **NIH application ID:** 10300655
- **Project number:** 3UL1TR001436-06S2
- **Recipient organization:** MEDICAL COLLEGE OF WISCONSIN
- **Principal Investigator:** Rahul S Nanchal
- **Activity code:** UL1 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $1,731,898
- **Award type:** 3
- **Project period:** 2020-12-15 → 2025-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10300655

## Citation

> US National Institutes of Health, RePORTER application 10300655, Clinical and Translational Science Award (3UL1TR001436-06S2). Retrieved via AI Analytics 2026-05-21 from https://api.ai-analytics.org/grant/nih/10300655. Licensed CC0.

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