# Validation of a New Stroke Simulation Model for Evaluating Stroke Prevention and Treatment Policies in Type 2 Diabetes Patients

> **NIH NIH R21** · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2021 · $429,000

## Abstract

Stroke is one of the atherosclerotic cardiovascular diseases that are the leading cause of
morbidity and mortality for people with type 2 diabetes (T2DM) and are the largest contributor to
the direct and indirect costs of T2MD. Despite improvements in the management of type T2MD,
the implementation level of these preventive interventions and treatment for T2MD
complications is still suboptimal. Substantial opportunity exists to further improve diabetes
control to prevent primary stroke and improve early management to reduce stroke related
morbidity, mortality, and cost. We will first validate a new stroke microsimulation model for
T2DM that reflects the modern paradigm of diabetes progression, stroke management, and
treatment. This model will then be used to evaluate the cost-effectiveness of enhanced levels of
implementing seven primary prevention strategies and expanding the current acute ischemic
stroke treatment guideline to include selected wake-up stroke patients based on perfusion
imaging for stroke in T2DM patients from a national perspective. The results of the evaluation
will advance scientific knowledge and will have major implications for health policies for stroke
prevention and treatments in type 2 diabetes patients.

## Key facts

- **NIH application ID:** 10302406
- **Project number:** 1R21NS120223-01A1
- **Recipient organization:** UNIVERSITY OF MICHIGAN AT ANN ARBOR
- **Principal Investigator:** Wen Ye
- **Activity code:** R21 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $429,000
- **Award type:** 1
- **Project period:** 2021-08-01 → 2024-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10302406

## Citation

> US National Institutes of Health, RePORTER application 10302406, Validation of a New Stroke Simulation Model for Evaluating Stroke Prevention and Treatment Policies in Type 2 Diabetes Patients (1R21NS120223-01A1). Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/grant/nih/10302406. Licensed CC0.

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