# Core-005

> **NIH NIH P30** · UNIVERSITY OF SOUTHERN CALIFORNIA · 2021 · $632,640

## Abstract

The Cell and Tissue Imaging Core provides advanced cell and tissue imaging technology, services, and 
scientific consultation. The Core facilitates scientific collaboration and advances the ability of USC Norris 
members to conduct innovative cancer research. Since its founding 15 years ago, the Cell and Tissue Imaging 
Core has been continuously approved and funded by the NCI CCSG. The facility has been ably led by the 
founding Director, Dr. David Hinton, and supervised by Technical Director, Ernesto Barron, both of whom have 
over 30 years of experience in the field of microscopy. In 2014, Dr. Scott Fraser, an internationally recognized 
innovator in imaging technology, was recruited to USC from Caltech. With the goal of providing national 
leadership in imaging technology through the facility, Dr. Fraser joined Dr. Hinton as Co-Director effective 
January 2015. 
The Cell and Tissue Imaging Core makes it possible for Cancer Center members to easily access a wide 
range of sophisticated imaging equipment and services, including laser scanning confocal/multiphoton 
microscopy, live cell spinning disk confocal imaging, transmission electron microscopy (TEM), scanning 
electron microscopy (SEM), digital light and fluorescence microscopy, fluorescence and bright field laser 
capture microdissection, thin sectioning, cryo-sectioning and embedding techniques, and computer aided 
graphics. In its effort to provide state-of-the-art technology, the Core is adding new instrumentation: a STORM 
super-resolution single-molecule imaging fluorescence microscope, a Two-Photon SPIM light sheet imager, a 
Flip Trap imaging scope, and a novel Hyperspectral Phasor Imaging (HPI) instrument. As a part of its mission 
to help members learn how Core resources can advance their research, the Core has an active education and 
training program through which it advises and instructs USC Norris investigators in novel methodologies and 
protocols to enhance their cell and tissue imaging capability. 
In FY 2013-2014, the Core was used by 36 Cancer Center members from six USC Norris Research Programs, 
which reflects both the quality of the service and the value of continued education and training efforts. In the 
fall of 2015, the Core will relocate to renovated space in USC Norris Topping Tower. Closer proximity to the 
majority of users and increased overall visibility should result in increased usage in the next project period.

## Key facts

- **NIH application ID:** 10303167
- **Project number:** 3P30CA014089-45S7
- **Recipient organization:** UNIVERSITY OF SOUTHERN CALIFORNIA
- **Principal Investigator:** CARYN LERMAN
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $632,640
- **Award type:** 3
- **Project period:** 1996-12-01 → 2021-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10303167

## Citation

> US National Institutes of Health, RePORTER application 10303167, Core-005 (3P30CA014089-45S7). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10303167. Licensed CC0.

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