# Core-007

> **NIH NIH P30** · UNIVERSITY OF SOUTHERN CALIFORNIA · 2021 · $811,134

## Abstract

The Molecular Genomics Core provides high-throughput analysis of genetic and epigenetic variations to 
researchers and clinicians of the USC Norris. The Core has two well-developed and differentiated sites: Health 
Sciences Campus (HSC) and Children’s Hospital Los Angeles (CHLA). The HSC site works with research 
samples, while the CHLA site specializes in providing services in a CLIA-compliant environment. The facility is 
led by Dr. David Van Den Berg, who has served as Core Director since 1999, with the support of two Co- 
Directors: Dr. Timothy Triche, CHLA, since 1999, and Dr. Charles Nicolet, HSC, since 2011. The Core 
continues to provide Cancer Center members with high-throughput biospecimen processing, DNA profiling of 
genetic variation, epigenetic profiling of DNA methylation and chromatin conformation, and expression 
profiling. 
At the time of the last CCSG renewal, the Molecular Genomics Core received a merit rating of excellent to 
outstanding. During the project period, the Core has acquired additional hardware platforms (Nanostring 
nCounter, Taqman Low Density Arrays, Ion Torrent PGM and Protons, Fluidigm BioMark, 2 x Illumina MiSeq 
and 2 x Illumina NextSeq500) to supplement existing capabilities for analysis of genetic variation, epigenetic 
variation and gene expression. It served as the only data production site for methylation assays for The Cancer 
Genome Atlas (TCGA), one of only a few sites processing the HumanOncoArray beadchip the OncoChip 
Consortium, and one of the largest Illumina single nucleotide polymorphism (SNP) and DNA methylation array 
production sites in the US. The facility has also supported the NCI Children’s Oncology Group (COG) and NCI 
funded TARGET program, which is profiling childhood cancer akin to TCGA’s role in adult cancer. 
In FY 2013-2014, 101 Cancer Center members (48% of users), of which 80 were peer-reviewed funded (38% 
of users) from seven Research Programs used the Molecular Genomics Core to accomplish their research 
objectives. The Core will continue to utilize expertise in high-throughput platforms to provide cost-effective 
options from single base to genome-wide analysis. The Core will continue to identify new technologies and 
services that may be offered to advance USC Norris research and to evaluate existing services for costeffectiveness 
and value added.

## Key facts

- **NIH application ID:** 10303169
- **Project number:** 3P30CA014089-45S7
- **Recipient organization:** UNIVERSITY OF SOUTHERN CALIFORNIA
- **Principal Investigator:** CARYN LERMAN
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $811,134
- **Award type:** 3
- **Project period:** 1996-12-01 → 2021-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10303169

## Citation

> US National Institutes of Health, RePORTER application 10303169, Core-007 (3P30CA014089-45S7). Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/grant/nih/10303169. Licensed CC0.

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