# TRANSCRIPTIONAL REGULATION OF ANTIBODY RESPONSES AND IMMUNITY

> **NIH NIH R01** · UNIVERSITY OF ARIZONA · 2022 · $460,500

## Abstract

Abstract: The duration of antibody responses varies widely with the specific vaccine or infection. The specific
features of the immunogen and host responses that are responsible for these differences remain poorly
understood. In this application, we describe two transcription factors of the BTB/POZ family which exert
opposing effects on the duration of antibody production. The first of these factors, Zbtb20, promotes plasma
cell survival and is required for primary long-term antibody responses when aluminum salts, but not Toll-like
receptor ligands are used as the adjuvant. The second factor, Zbtb32, promotes plasma cell death and limits
the duration of antibody production following memory B cell recall responses, but not primary antibody
responses. Based on these findings, we propose to establish the cellular events that explain how adjuvants
influence the duration of immunity, and to uncover the physiological consequences to the diversity of antibody
responses when recall responses persist for too long. Moreover, we propose to identify the molecular
mechanisms of how Zbtb20 and Zbtb32 function to control the duration of humoral immunity.

## Key facts

- **NIH application ID:** 10304171
- **Project number:** 5R01AI099108-10
- **Recipient organization:** UNIVERSITY OF ARIZONA
- **Principal Investigator:** Deepta Bhattacharya
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $460,500
- **Award type:** 5
- **Project period:** 2012-09-24 → 2023-05-07

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10304171

## Citation

> US National Institutes of Health, RePORTER application 10304171, TRANSCRIPTIONAL REGULATION OF ANTIBODY RESPONSES AND IMMUNITY (5R01AI099108-10). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10304171. Licensed CC0.

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