This program project application for the Alcohol Research Consortium on HIV (ARCH)* builds on and extends our very successful administrative and research accomplishments over the past 9 years of NIAAA support. Combining expertise and experience across disciplines and Universities, the ARCH consortium consists of the Administrative Core (ARCH-AC), the Biostatistics/Methods Core (ARCH-BMC), the epidemiological research component (ARCH- ERA) and the implementation research component (ARCH-IRA) and the relapse prevention research component (ARCH-RPA). The ARCH Administrative Core (ARCH-AC) provides the infrastructure for oversight, coordination and direction to these program project components, and facilitates the overarching P01 scientific goals as well as the project aims of ARCH cores and components. ARCH-AC builds on the administrative structure established during our previous funding periods, and includes: a Steering Committee (chaired by the ARCH-AC MPIs and including the Project Leads of the BMC and three research components); Component Working Committees (chaired by the component Project Lead(s) with participation by component faculty, staff and mentees, and participation by AC and BMC staff as appropriate/needed), and the Program Advisory Committee (PAC), an outstanding, already established board of advisors with national and international expertise in HIV, clinical cohorts, epidemiology, psychology, implementation research, alcohol use disorder. In addition to coordinating and documenting a regular meeting schedule across the different committees, ARCH-AC also uses multiple well-established administrative processes for monitoring project milestones and quality control, overseeing resource allocation and coordination, ensuring regulatory compliance, mentoring students and junior faculty, and disseminating new knowledge through publications, presentations and a project website. ARCH-AC is led by national experts in alcohol and HIV research and services, who have combined experience in conducting epidemiologic and clinical research in HIV/AIDS and alcohol use. The ARCH-AC MPIs have primary responsibility for maintaining communication and collaborative relationships with external organizations including CNICS, JHU and US CFARs, NIAAA and other program projects funded under this announcement. ARCH-AC synergizes the proposed epidemiological and intervention research critical to address NIH and End the HIV Epidemic priorities.