PROJECT SUMMARY/ABSTRACT Effective antiretroviral therapy has increased the lifespan of people living with HIV (PLWH). Alcohol use, common among PLWH, plays an important role in the risk for and management of HIV-associated comorbidities. Unhealthy alcohol use can exacerbate two prevalent HIV-related co-occurring conditions, chronic pain and physical inactivity, which in conjunction with alcohol use affect physical and mental function and are associated with a variety of HIV-related comorbidities. We propose the Boston Alcohol Research Collaboration on HIV/AIDS – Comorbidity Center (Boston ARCH CC) as an extension of the Boston Alcohol Research Collaboration of HIV/AIDS (ARCH). In Boston ARCH CC two clinical trials will test interventions aimed at unhealthy alcohol use, pain, and physical inactivity, that impact a variety of other HIV- related comorbidities. The ARCH CC BDM Core will work closely with ARCH CC investigators, providing experience, expertise, and resources toward the planning, conduct, and data analysis of the work of Boston ARCH CC. ARCH CC will also continue to make the existing Boston ARCH Cohort available for secondary analyses, with a focus on mentoring and developing young investigators, and the ARCH CC BDM Core will provide support for developing proposals and conducting analyses of the cohort. The first aim of the ARCH CC BDM Core is to provide comprehensive data management and statistical support for the two ARCH CC clinical trials. Both of these trials focus on behavioral telehealth interventions. Research Project Component-Pain tests the efficacy of an integrated telehealth intervention incorporating motivational and cognitive-behavioral management for reducing unhealthy drinking and chronic pain in PLWH. Research Project Component-Physical Activity tests the efficacy of a home-based lifestyle physical activity intervention with mobile-health delivered components to decrease unhealthy drinking and increase physical activity in PLWH. The second aim of ARCH CC BDM is to support secondary analyses of the existing Boston ARCH cohort, and provide support and mentoring to trainees and investigators accessing the cohort. The Boston ARCH cohort enrolled PLWH with current or past unhealthy alcohol use, collecting longitudinal data on alcohol and other drug use and disorders, HIV-related treatment and medication use, health-related behaviors, and physical and mental function outcomes.