The mission of the Development Core (DC) of the Philadelphia Regional Center for Children's Environmental Health (PRCCEH) is to cultivate the career development and provide career training for the next generation of scientists in children's environmental health (CEH) so that they can become independent productive scientists conducting innovative research in CEH. Dr. Rebecca Simmons will be the Director and Dr. Aimin Chen will be the Co-Director. We will also identify and encourage early-stage investigators (ESIs) as well as investigators whose research could be expanded into CEH areas. Special emphasis is placed on developing the skills necessary for translating research findings in CEH. Women and underrepresented minorities will be strongly encouraged to participate. Another major function of the DC is to bring together ESIs from all of the institutions in the PRCCEH to provide a coordinated Children's Environmental Health Scientist Support Program. This mission is accomplished by: a) maintaining a data-base of all ESIs conducting research in environmental health science; (b) forming a mentoring committee and developing a formalized career development plan for ESIs; (c) identifying candidates that can apply for Pilot Project funding, as well as extramural funding; (d) identifying and supporting under-represented minority ESIs in CEH. These goals will be accomplished by the following specific aims: Aim 1. Maintain a data-base of all Early-Stage Investigators conducting research in CEH; Aim 2. Establish the Children's Environmental Health Scientist Support Program for Early-Stage Investigators in the PRCCEH. The goal of our Children's Environmental Health Scientist Support Program is to provide a transformative experience so that our ESIs will be equipped with the tools for success as the next generation of CEH scientists. This will be achieved through a PRCCEH mentoring program, PRCCEH Annual Mentorship Retreat, a Grant Proposal Review Program, CEH workshops, recruitment and support of CEH under-represented minorities, continuing education programs, and PRCCEH professional skill training; Aim 3. Build capacity in children's environmental health sciences research through the Catalyst Pilot Program; Aim 4. Enhance translational knowledge and capacity of ESI through mentored engagement with regulators, legislators and community organizations relevant to their research. ESIs will be encouraged to engage in a translational capacity building program called Community Children's Environmental Health. ESIs will have a translational experience in regulatory, legislative and community engagement. ESI's will engage either on-site or virtually, learning about the organization's work and identifying opportunities to translate their CEH work. Aim 5. Establish the Community-partner participatory support program. We will establish a community-based mentoring program that will build capacity in community-partner participation. The goals include enhanced community ...