# Mechanisms of temporal selectivity in the anuran auditory midbrain

> **NIH NIH R01** · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · 2022 · $324,063

## Abstract

The temporal structure of signals plays important roles in communication.  The proposed projects 
aim to provide new insight into how midbrain neurons respond selectively to particular temporal 
features of communication sounds, specifically pulse rate and duration. Experiments will 
investigate the role of NMDA-type receptors in amplifying responses and augmenting temporal 
selectivity.   Other experiments will be the first to explore the role of projections from the 
nucleus of the lateral lemniscus to the inferior colliculus in generating temporal selectivity.  
Focal pharmacological manipulations will be combined with whole-cell intracellular recordings.  We 
also propose to use new computational methodology to delineate the time course of excitatory and 
inhibitory conductances.  This novel and powerful methodological approach has only recently been 
applied to the in vivo study of central auditory systems (Rose et al., 2013), and holds great 
promise for enabling auditory system researchers, as well as the neuroscience community at large, 
to gain unprecedented insight into the mechanisms that underlie computations in the brain.  This 
approach will also be used to investigate the roles of dynamic properties of inhibition, and thereby 
evaluate a new model of interval selectivity.  The last set of experiments will investigate whether IC 
neurons of the various temporal selectivity classes respond selectively to particular natural calls of 
leopard frogs.  These new experiments are expected to further our understanding of the network 
and cellular properties that underlie the temporal selectivity of midbrain neurons.

## Key facts

- **NIH application ID:** 10307545
- **Project number:** 5R01DC017466-04
- **Recipient organization:** UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH
- **Principal Investigator:** GARY J ROSE
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $324,063
- **Award type:** 5
- **Project period:** 2018-12-01 → 2023-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10307545

## Citation

> US National Institutes of Health, RePORTER application 10307545, Mechanisms of temporal selectivity in the anuran auditory midbrain (5R01DC017466-04). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10307545. Licensed CC0.

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