# Lineage heterogeneity and plasticity in lung cancer

> **NIH NIH R01** · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2021 · $65,620

## Abstract

PROJECT SUMMARY
This is an application for a Research Supplement to Promote Diversity in Health-Related Research (PA-20-222).
The parent R01 project associated with this application is entitled “Lineage Heterogeneity and Plasticity in Lung
Cancer” supported by NCI (5R01CA240342 -02). Douglas Mansell is the diversity candidate. He is a US citizen
of African-American descent and is currently a postdoctoral fellow at Icahn School of Medicine at Mount Sinai,
New York. The main goal of this study is to characterize the significance of one of our lead candidates PBX1
defining the lineage state of a novel subset of lung adenocarcinoma. We will test the subclass-specific local
chromatin structure and then investigate the roles of novel lineage transcription factors specifically enriched in
the subgroup of lung adenocarcinoma, whether they are essential for maintaining the cellular state of lung cancer
cells and are dependent on the committed lineage for their survival.

## Key facts

- **NIH application ID:** 10310542
- **Project number:** 3R01CA240342-02S1
- **Recipient organization:** ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- **Principal Investigator:** Hideo Watanabe
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $65,620
- **Award type:** 3
- **Project period:** 2019-09-20 → 2024-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10310542

## Citation

> US National Institutes of Health, RePORTER application 10310542, Lineage heterogeneity and plasticity in lung cancer (3R01CA240342-02S1). Retrieved via AI Analytics 2026-05-28 from https://api.ai-analytics.org/grant/nih/10310542. Licensed CC0.

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