# Treatment of Status Epilepticus

> **NIH NIH R01** · UNIVERSITY OF VIRGINIA · 2021 · $125,000

## Abstract

Status epilepticus (SE) is a neurological emergency that afflicts 120-160,000 Americans each
year, which can cause brain damage and contribute to mortality. Approximately one third of
patients in SE are refractory to current therapies. We will investigate the role of AMPA receptor
plasticity in benzodiazepine resistant SE using genetically modified mice, advanced imaging
and electrophysiology; and we will test a novel therapy. In Aim 1, we propose to test whether a
single seizure and SE enhance AMPAR mediated synaptic transmission in activated CA1
pyramidal neurons and the entorhinal cortex using patch clamp electrophysiology and
biochemical techniques. The experiments in Aim 2 test the role of GluA1 plasticity in seizure
spread and duration using global and conditional knockout mice. In Aim 3, we test the efficacy
of IEM 1460, a drug that targets modified AMPA receptors, in terminating SE. This project will
provide novel insights into the mechanisms of SE initiation by repeated seizures. It will define
the role of GluA1 subunit plasticity in seizure spread during benzodiazepine refractory SE; and
provide the neurobiological basis for the development and use of drugs targeting calcium
permeable AMPA receptors for terminating SE.

## Key facts

- **NIH application ID:** 10310543
- **Project number:** 3R01NS040337-16S1
- **Recipient organization:** UNIVERSITY OF VIRGINIA
- **Principal Investigator:** Jaideep Kapur
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $125,000
- **Award type:** 3
- **Project period:** 2000-09-15 → 2021-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10310543

## Citation

> US National Institutes of Health, RePORTER application 10310543, Treatment of Status Epilepticus (3R01NS040337-16S1). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10310543. Licensed CC0.

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