# Role of UHRF1 in osteosarcoma metastasis

> **NIH NIH R01** · UNIVERSITY OF CALIFORNIA-IRVINE · 2021 · $111,135

## Abstract

Project Summary
This Diversity Supplement application builds on a parental grant studying the genetic alterations at the RB
transcriptional corepressor 1 (RB1) gene that are associated with increased mortality, metastasis and poor
response to chemotherapy in osteosarcoma. We recently identified ubiquitin-like, containing PHD and RING
finger domains-1 (UHRF1), as a key epigenetic regulator that is upregulated in osteosarcoma. Our preliminary
studies suggest that UHRF1 overexpression results in increased cell proliferation, migration, invasion, and
metastasis. For this supplement, we propose to expand the scope of our parental grant to elucidate the
mechanisms through which UHRF1 overexpression in osteosarcoma contributes to tumor invasion and
metastasis. We propose to examine the role of UHRF1 on the interaction between cancer cells and the tumor
microenvironment through exosome alterations. Exosomes have been identified as an important factor in the
modulation of cancer and stromal cells towards induction of a metastatic phenotype. We hypothesize that UHRF1
overexpression contributes to altered exosome formation and/or exosomal cargo and this contributes to
metastasis in osteosarcoma. Overall, this research proposal will broaden our understanding of the role of UHRF1
in osteosarcoma metastasis.

## Key facts

- **NIH application ID:** 10310790
- **Project number:** 3R01CA229696-03S1
- **Recipient organization:** UNIVERSITY OF CALIFORNIA-IRVINE
- **Principal Investigator:** Claudia Andrea Benavente
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $111,135
- **Award type:** 3
- **Project period:** 2019-06-01 → 2024-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10310790

## Citation

> US National Institutes of Health, RePORTER application 10310790, Role of UHRF1 in osteosarcoma metastasis (3R01CA229696-03S1). Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/grant/nih/10310790. Licensed CC0.

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