# A Mobile TXT-based Intervention to Improve Adherence to Adjuvant Hormone Therapy and Symptom Management for BCa Survivors

> **NIH NIH R01** · THOMAS JEFFERSON UNIVERSITY · 2021 · $184,506

## Abstract

Breast cancer (BCa) is the leading cause of mortality in Hispanic women and the most commonly diagnosed
cancer in this minority group, the largest and fastest growing ethnic group in the US. Compared with other
racial/ethnic groups, Hispanic women have a higher rate of discontinuation of adjuvant hormone therapy (AHT)
treatment. This finding is particularly relevant because the gap between Hispanic and NHW women in BCa
survival is known to be largest among estrogen-sensitive subtypes in whom prolonged AHT treatment over
years is key to improving outcomes. Because nonadherence has been shown to affect survival outcomes and
increase mortality, differential utilization of AHT may contribute in part to the disparities in Hispanic BCa
outcomes. Guided by our team's Cognitive-Social Health Information Processing Model and health
communication best practices, an evidence-based mobile text messaging intervention (Txt2Adhere), designed
to promote adherence to AHT, was iteratively developed with patient-centered input and clinical and behavioral
evaluation during year 1 of the Parent Grant. The proposed supplement research study is a logical extension of
this line of research in the area of adherence promotion to anticancer oral treatment, while at the same time
adding Dr. Clara Granda-Cameron's (the supplement grant candidate) expertise by providing training in the
intersection of BCa health disparities and mHealth research, and adapting a theory-guided and carefully-tested
intervention prototype of use with an underserved segment of BCa population. We will first examine Hispanic
BCa survivors' perceived barriers and facilitators on adherence to AHT through a qualitative study. Guided by
a Hispanic community advisory board and the qualitative findings, we will adapt the Parent Grant intervention
“Txt2Adhere” to a linguistically-appropriate and culturally-informed intervention (MeCuido) for Hispanic BCa
survivors through a 3-stage cultural adaptation and formative evaluation process. Three priority training areas,
1) qualitative and quantitative research methodologies, 2) health disparities in minority populations, and 3)
mHealth and health communication, are identified to enhance Dr. Granda-Cameron's understanding of the
methodologies and results of the proposed supplement study. Training will be implemented through formal
coursework, local and national workshops, seminars and training institutes, as well as continuous interaction
with mentors and advisors with relevant expertise. Dr. Kuang-Yi Wen (PI of the Parent Grant) and Dr. Ana
Maria Lopez will provide their mentorship and guidance to 1) facilitate the progression of Dr. Granda-
Cameron's training activities, 2) guide the implementation of the proposed supplement research project, and 3)
promote Dr. Granda-Cameron's transition to an independent investigator. This study is significant because
MeCuido has the potential to reduce disparities in AHT adherence among Hispanic BCa women and will
provide Dr...

## Key facts

- **NIH application ID:** 10310855
- **Project number:** 3R01CA222246-03S1
- **Recipient organization:** THOMAS JEFFERSON UNIVERSITY
- **Principal Investigator:** Kuang-Yi Wen
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $184,506
- **Award type:** 3
- **Project period:** 2019-06-11 → 2024-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10310855

## Citation

> US National Institutes of Health, RePORTER application 10310855, A Mobile TXT-based Intervention to Improve Adherence to Adjuvant Hormone Therapy and Symptom Management for BCa Survivors (3R01CA222246-03S1). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10310855. Licensed CC0.

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