# Anxa2 drives the function of immune suppressive neutrophils in lung cancer

> **NIH NIH R01** · FRED HUTCHINSON CANCER RESEARCH CENTER · 2021 · $40,193

## Abstract

ABSTRACT
Although immune checkpoint inhibitor (ICI) therapy has been a tremendous clinical success, just ~20% of non-
small cell lung cancer (NSCLC) patients respond to anti-PD1/PDL1 therapy. In efforts to improve upon this figure,
the field has launched over 800 clinical trials (across all cancer types) testing novel therapeutics in conjunction
with immune checkpoint blockade. Unfortunately, such trials have been based largely on theoretical
considerations and not by data obtained from actual human cancer specimens. Notably, very few of these trials
address myeloid lineage cells and none of them address the neutrophil lineage. Our group recently undertook a
comprehensive immune phenotyping project to identify potential immune suppressive factors in human NSCLC.
We found that neutrophils were the most prevalent immune cell type out of the 51 immune cell types and
subtypes assessed. More importantly, the presence of neutrophil lineage cells inversely correlated with CD8+
lymphocyte content within the TME. Here, we will show tumor-derived Annexin-A2 polarizes neutrophils to an
immune suppressive phenotype and determine the mechanisms by which it does so. More importantly, this
project will provide the necessary training ground for the graduate student to obtain the skills and critical
examination of data to progress in his career towards an independent scientist.

## Key facts

- **NIH application ID:** 10310981
- **Project number:** 3R01CA221295-03S1
- **Recipient organization:** FRED HUTCHINSON CANCER RESEARCH CENTER
- **Principal Investigator:** A McGarry Houghton
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $40,193
- **Award type:** 3
- **Project period:** 2021-03-01 → 2023-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10310981

## Citation

> US National Institutes of Health, RePORTER application 10310981, Anxa2 drives the function of immune suppressive neutrophils in lung cancer (3R01CA221295-03S1). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10310981. Licensed CC0.

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