# Core A - Clinical Database.

> **NIH NIH P01** · WASHINGTON UNIVERSITY · 2022 · $332,134

## Abstract

CORE A SUMMARY/ABSTRACT
The main objective of this core is the enrollment of every patient AML and MDS referred to Washington University
into the Tissue Acquisition and Clinical Database protocol of the GAML program project. Skin, oral mucosa, bone
marrow, peripheral blood leukocytes and serum specimens collected from patients will be banked and processed
by Core B, (Specimen Database), whereupon they will serve as the basis for genomic analyses outlined in Core
C (Sequencing and Analysis), to be utilized in Projects 1-4. This Clinical Core will also maintain and expand a
comprehensive database that captures essential clinical, pathological, karyotypic, molecular, therapeutic, and
outcomes data of enrolled AML and MDS patients, anonymously linked with the corresponding tissue specimens.
The Clinical Core database will provide key clinical annotation for the samples prepared by Core B, and genomic
studies performed by Core C, which will be utilized by Projects 1-4.
Specific Aim/Core Service 1:
We will attempt to prospectively enroll and collect tissue at diagnosis, in remission, and at relapse from every
patient referred to the Washington University Siteman Cancer Center with AML and MDS.
Specific Aim/Core Service 2:
We will maintain a comprehensive clinical leukemia database that will capture epidemiological data, disease-
related characteristics, prognostic factors, therapeutic information, and outcomes data from all enrolled AML and
MDS patients, with de-identified linkage to corresponding banked tissue specimens.
Specific Aim/Core Service 3:
We will provide statistical and informatics support for all PPG activities, including sample size assessments for
human and mouse studies, detailed statistical evaluations of all datasets for publications, and IT support for
database management.

## Key facts

- **NIH application ID:** 10311213
- **Project number:** 5P01CA101937-18
- **Recipient organization:** WASHINGTON UNIVERSITY
- **Principal Investigator:** PETER WESTERVELT
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $332,134
- **Award type:** 5
- **Project period:** 2003-09-19 → 2023-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10311213

## Citation

> US National Institutes of Health, RePORTER application 10311213, Core A - Clinical Database. (5P01CA101937-18). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10311213. Licensed CC0.

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