# The Role of Coagulation Factor XII in Medical Device-induced Thrombosis

> **NIH NIH F31** · OREGON HEALTH & SCIENCE UNIVERSITY · 2021 · $36,954

## Abstract

Project Summary
Blood-contacting medical devices, such as catheters, vascular grafts, and stents, are often required to treat
cardiovascular diseases. A major cause of device failure is intraluminal blood clot formation, also known as
thrombus formation or thrombosis. Thrombosis hinders blood flow and can lead to myocardial infarction or stroke,
due to tissue death. Anticoagulants are used to prevent and reduce the incidence of thrombosis on medical
devices. However, current therapies target important hemostatic factors, which often leads to detrimental
bleeding side effects. Factor (F) XII is a coagulation factor that has been implicated in thrombosis, but has no
known role in hemostasis. Therefore, it has been suggested FXII could be a safe target for the next-generation
of anticoagulants and this has been supported by early studies. Despite the promise of FXII-targeted therapies,
the mechanisms of FXII activation that lead to thrombosis on cardiovascular medical devices remain unknown.
I hypothesize that thrombosis on medical devices is dependent on FXIIa-fibrin and FXII-platelet interactions at
the blood-device interface. The proposed work aims to (1) determine the role of FXIIa in the modulation of fibrin
formation and structure in medical device-induced thrombosis and (2) determine the role of device-activated
platelets on FXII activation in medical device-induced thrombosis. Determining how FXII activation promotes
thrombosis on medical devices will aid in the development of effective and safe FXII-targeted anticoagulants.
FXII specific anticoagulants could reduce or eliminate morbidity and mortality in patients suffering from medical
device-related thrombosis. The proposed work will investigate interactions between FXII and major components
of a thrombus on medical device materials.

## Key facts

- **NIH application ID:** 10311464
- **Project number:** 1F31HL159891-01
- **Recipient organization:** OREGON HEALTH & SCIENCE UNIVERSITY
- **Principal Investigator:** Novella Bates
- **Activity code:** F31 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $36,954
- **Award type:** 1
- **Project period:** 2021-08-20 → 2022-06-17

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10311464

## Citation

> US National Institutes of Health, RePORTER application 10311464, The Role of Coagulation Factor XII in Medical Device-induced Thrombosis (1F31HL159891-01). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10311464. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*