The goal of this project is to establish robust, proof-of-concept feasibility for an innovative E-nose system, termed the MOF-SCENT system, for real-time and non-invasive screening for asymptomatic and symptomatic COVID-19 patients, with high accuracy based on the detection of VOCs emanating from exhaled breath. The proposed OE-HCCR-MOF based E-nose sensor is a novel biosensing and chemical sensing technology that will fundamentally advance E-nose sensing technologies due to the improved sensitivity and selectivity.