# Translation of epidemiologic findings in enteric disease to public health action

> **NIH NIH K01** · EMORY UNIVERSITY · 2022 · $118,012

## Abstract

PROJECT SUMMARY/ABSTRACT
Epidemiologic studies are critical for understanding the diverse drivers of enteric infections and malnutrition,
which lead to recurrent diarrheal illnesses and poor growth among children in low-resource settings. To
accelerate the translation of population-based data into policy-ready, actionable evidence, novel epidemiologic
methods have recently been developed to assess the generalizability of results and estimate the impact of
potential interventions from observational data. In this K01 Mentored Research Scientist Development Award
application, Dr. Elizabeth T. Rogawski, an Assistant Professor in Public Health Sciences at the University of
Virginia (UVA), proposes to apply these innovative methods to inform the implementation of results from two
multisite observational studies of enteric infections and two single-site randomized intervention trials in South
Africa and Tanzania. The observational studies are MAL-ED, an 8-site birth cohort study of enteric infections,
diarrhea, and child development, and GEMS, a 7-site case-control study of moderate-to-severe diarrhea.
Specifically, Dr. Rogawski will: 1) identify site-specific social and environmental factors that modify the impact
of risk factors for diarrhea and poor growth in MAL-ED and translate effect estimates to GEMS sites using
inverse-probability weighting methods; 2) estimate the impact of realistic public health interventions to reduce
diarrheal risk and improve child growth from the observational data using the parametric g-formula; and 3)
estimate the impact of interventions assessed in the randomized trials of a drinking water quality intervention
(South Africa) and a multifactorial child health intervention (Tanzania) at the other MAL-ED and GEMS sites.
Key risk factors and potential targets of intervention include water, sanitation, and hygiene-associated factors,
enteric pathogens, antimicrobial use, macro- and micronutrients, and illnesses. Dr. Rogawski proposes a
career development plan that includes mentorship, fieldwork, coursework, publications, and presentations. Her
proposal will be supervised by an outstanding mentoring team with complementary methodological,
substantive, and clinical skills. The wealth of research and mentorship experience, robust training
infrastructure, and longstanding international collaborations at UVA make this institution the ideal environment
to support these activities. Her goals for the award are to become an expert in enteric infections and
environmental enteropathy, develop proficiency in novel epidemiologic causal inference methods that are
relevant to implementation research, and successfully transition to independence Through an academic
career in epidemiology maintain an international research program in pediatric infectious diseases
based in the US, while developing
.
, she plans to
novel analytic methods to facilitate the presentation of impactful
epidemiologic results.
The K01 Mentored Research Scientist Deve...

## Key facts

- **NIH application ID:** 10312787
- **Project number:** 5K01AI130326-06
- **Recipient organization:** EMORY UNIVERSITY
- **Principal Investigator:** Elizabeth Tacket Rogawski McQuade
- **Activity code:** K01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $118,012
- **Award type:** 5
- **Project period:** 2021-09-01 → 2023-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10312787

## Citation

> US National Institutes of Health, RePORTER application 10312787, Translation of epidemiologic findings in enteric disease to public health action (5K01AI130326-06). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10312787. Licensed CC0.

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