# Otud1-mediated Prevention of Sarcopenic Obesity during Resistance Exercise Training on High-Fat Diet

> **NIH NIH F32** · UNIVERSITY OF VIRGINIA · 2021 · $52,755

## Abstract

Project Summary
Anabolic resistance in sarcopenic obesity is a growing concern in the aging population. Increased risk for insulin
resistance, type II diabetes, and cardiovascular disease are present in sarcopenic obesity. Developing therapies
to combat sarcopenic obesity is of interest to researchers and healthcare professionals. Resistance exercise is
one method that is effective in promoting improved glucose uptake and combating diabetes. The mechanistic
pathways of resistance exercise are not completely understood and require further dissection under careful
controlled conditions. I will use mouse models with these weightlifting cages to promote improvements in skeletal
muscle metabolic function. Eight weeks of weight training has proven to be effective in improving body
composition and glucose uptake in mice fed high-fat diet. I will also use aged mice on HFD to examine the effects
of resistance training in combating sarcopenic obesity. I will also use a genetic approach to examine the proteins
that may govern metabolic function. This study will determine how resistance exercise improves glucose uptake
under metabolic stress. These finding may help to develop exercise guideline and potential drug targets for better
treatments in diabetes.

## Key facts

- **NIH application ID:** 10313292
- **Project number:** 1F32AG074528-01
- **Recipient organization:** UNIVERSITY OF VIRGINIA
- **Principal Investigator:** Robert James Shute
- **Activity code:** F32 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $52,755
- **Award type:** 1
- **Project period:** 2021-09-30 → 2022-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10313292

## Citation

> US National Institutes of Health, RePORTER application 10313292, Otud1-mediated Prevention of Sarcopenic Obesity during Resistance Exercise Training on High-Fat Diet (1F32AG074528-01). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10313292. Licensed CC0.

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