# Understanding the contribution of altered cerebrovascular function to the pathology and clinical symptoms of Huntington disease

> **NIH NIH R01** · MASSACHUSETTS GENERAL HOSPITAL · 2022 · $668,509

## Abstract

PROJECT SUMMARY/ABSTRACT: This proposal seeks to establish the pathophysiological mechanisms that
establish a relationship between neurovascular dysfunction, neurological impairment and brain degeneration in
Huntington’s disease (HD). It builds on our growing understanding of the important of neurovascular alterations
in neurodegeneration, including in HD, and takes advantage of clinical and neuroimaging expertise as well as
the availability of a well-characterized cohort of HD gene-expanded individuals. Aim1 examines the cross-
sectional regional changes in cerebrovascular reactivity (CVR) and tests the hypothesis that impaired CVR
triggers focal brain atrophy. Aim 2 tests the specific hypothesis that impaired perfusion (CBF) occurs in HD and
is associated with regionally altered CVR. Aim 3 evaluates the longitudinal neurovascular changes and the
causal relationship between location and severity of these changes with rates of clinical progression and of brain
atrophy. Successful achievement of these aims will establish a strong foundation for understanding key vascular
mechanisms that may affect progression and HD and establish neurovascular mechanisms as important targets
for future clinical drug trials in HD

## Key facts

- **NIH application ID:** 10314055
- **Project number:** 5R01NS114562-02
- **Recipient organization:** MASSACHUSETTS GENERAL HOSPITAL
- **Principal Investigator:** HERMINIA Diana ROSAS
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $668,509
- **Award type:** 5
- **Project period:** 2020-12-15 → 2026-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10314055

## Citation

> US National Institutes of Health, RePORTER application 10314055, Understanding the contribution of altered cerebrovascular function to the pathology and clinical symptoms of Huntington disease (5R01NS114562-02). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10314055. Licensed CC0.

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