# Development of a Micro-ECoG Neuroprosthesis for Motor Rehabilitation in a Chronic Corticospinal Stroke Injury

> **NIH NIH R01** · WASHINGTON UNIVERSITY · 2022 · $530,959

## Abstract

In rehabilitating chronic motor-impaired stroke survivors with a brain computer interface (BCI), there is a
fundamental gap in understanding how the brain changes with injury and in how a BCI can engage these
dynamics to induce a functional recovery. The current barrier is the absence of a primate model that can test a
BCI strategy in chronic stroke. The majority of animal models employ gray matter lesions, while the majority of
clinically significant strokes involve the deeper white matter. The long-term goal of this project is to restore
motor function by synergizing the patient's BCI rehabilitative strategy with their specific stroke-induced
pathophysiology. The overall objective of this proposal is to create a nonhuman primate model for stroke that
will examine the evolving physiology following a microvascular corticospinal tract (CST) lesion and test the
impact of a neuroprosthetic intervention for functional restoration in the chronic setting. The central hypothesis
is that BCI-driven motor rehabilitation for a CST injury will be effective when the control signals from the
unaffected hemisphere are paired with proprioceptive feedback. The rationale for this research is that the
animal model and the accrued scientific insights will create a mechanism-driven approach to neuroprosthetic
solutions for stroke. Guided by strong preliminary evidence, we will test the central hypothesis with the
following three specific aims: 1) Create a cortical electrode to enable multimodal measurements of the brain
before and after a microvascular lesion to the CST, 2) Define acute and chronic alterations in cortical
physiology and behavioral performance associated with a microvascular lesion to the CST, and 3) Restore
motor function in macaque monkey with chronic CST injury using BCI rehabilitation. Under the first aim we will
create a bihemispheric, MRI-invisible, micro-electrocorticographic (µECoG) implant that can measure the
cortical physiology of ipsilesional and contralesional motor cortex and enable functional and anatomical
magnetic resonance imaging. In the second aim, this implant, along with a new method for creating a
stereotactic lesion to the posterior limb of the internal capsule, will enable us to link the micro-scale cortical
electrophysiology with larger scale functional imaging as the brain changes from the central insult. Under the
third aim, the chronically paretic monkeys will be rehabilitated using signal sources from the contralesional
hemisphere. This project is innovative because it is a substantial departure from the status quo by expanding
the role the unaffected hemisphere and bihemispheric interactions can play in BCI-mediated rehabilitation.
The proposed research will be significant because the knowledge will create a critical bridge between motor
function, electrophysiology, and functional imaging, which will vastly improve the characterization of how the
cortical dynamics are perturbed with a white matter stroke and subsequentl...

## Key facts

- **NIH application ID:** 10318158
- **Project number:** 5R01NS101013-05
- **Recipient organization:** WASHINGTON UNIVERSITY
- **Principal Investigator:** Eric CLAUDE Leuthardt
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $530,959
- **Award type:** 5
- **Project period:** 2017-12-01 → 2024-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10318158

## Citation

> US National Institutes of Health, RePORTER application 10318158, Development of a Micro-ECoG Neuroprosthesis for Motor Rehabilitation in a Chronic Corticospinal Stroke Injury (5R01NS101013-05). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10318158. Licensed CC0.

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