# Gene Regulation: Celebrating 40 Years of the Enhancer

> **NIH NIH R13** · KEYSTONE SYMPOSIA · 2021 · $16,200

## Abstract

ABSTRACT
Support is requested for a Keystone Symposia conference entitled Gene Regulation: Celebrating 40 Years of
the Enhancer, organized by Drs. Michael S. Levine and L. Stirling Churchman. The conference will be held in
Santa Fe, New Mexico from January 23-27, 2022.
Transcriptional control is at the heart of developmental and disease processes. Over decades, the field of
gene regulation continues to elucidate how interactions between regulatory factors and elements in genomic
DNA and nascent RNA control gene expression. This year, we celebrate the 40th anniversary of the
enhancer, genomic DNA distal to gene promoters that controls transcription. Therapeutic strategies have
struggled to target interactions between factors and cis-elements in DNA and RNA, but progress is now being
made through the development of new drugs and new approaches. Furthermore, new concepts and
technologies are revolutionizing our models of how transcription factors, chromatin and enhancers control
genes. The conference will explore new paradigms such as the interplay between transcriptional condensates
and genome topology and will stimulate debate on questions of mechanism and causality. This meeting aims
to bring together innovators developing new ways to manipulate and probe transcription, from small molecules
to single cell technology, with thought leaders working to define and elucidate gene regulatory mechanisms.
Participants will attend sessions on transcriptional mechanisms, from structural details to molecular
condensates, gene control in development, new technologies that observe and measure transcription in single
cells and a session celebrating the discovery of the enhancer. It is anticipated that attendees, especially
trainees, will leave the meeting excited by the field’s future and inspired by its history.

## Key facts

- **NIH application ID:** 10318496
- **Project number:** 1R13HG012151-01
- **Recipient organization:** KEYSTONE SYMPOSIA
- **Principal Investigator:** Thale Cross Jarvis
- **Activity code:** R13 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $16,200
- **Award type:** 1
- **Project period:** 2021-09-22 → 2022-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10318496

## Citation

> US National Institutes of Health, RePORTER application 10318496, Gene Regulation: Celebrating 40 Years of the Enhancer (1R13HG012151-01). Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/grant/nih/10318496. Licensed CC0.

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