# Cerebellar parvocellular modules

> **NIH NIH R21** · JOHNS HOPKINS UNIVERSITY · 2022 · $204,688

## Abstract

Project Summary
The cerebellum has been implicated in a remarkable number of neurological and neuropsychiatric
disorders that range from motoric deficits such as ataxia, tremor, and disequilibrium to autism,
schizophrenia, and impulsivity. We do not know why some patients with dysfunction in the cerebellum
experience primarily motoric symptoms while others suffer from dysregulated mood and mental health
challenges. In this proposal, we examine the specific neural circuits that are responsible for diverse
cerebellar motoric and non-motoric dysfunctions. Using a combination of rigorous anatomical methods,
including specialized viral circuit tracing vectors that provide new information about brainwide neuronal
connections, this research will test the hypothesis that specialized types of cerebellar output neurons
are differentially responsible for the diverse disorders associated with the cerebellum.
Accomplishments of these experimental goals will generate important new information about the brain-
wide connections made by different types of cerebellar output neurons which will enable the
development of new diagnostic and therapeutic strategies for patients with a wide range of motoric and
neuropsychiatric disorders.

## Key facts

- **NIH application ID:** 10319014
- **Project number:** 5R21MH125324-02
- **Recipient organization:** JOHNS HOPKINS UNIVERSITY
- **Principal Investigator:** SASCHA DU LAC
- **Activity code:** R21 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $204,688
- **Award type:** 5
- **Project period:** 2020-12-15 → 2022-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10319014

## Citation

> US National Institutes of Health, RePORTER application 10319014, Cerebellar parvocellular modules (5R21MH125324-02). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10319014. Licensed CC0.

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