# Nonlinear Models of Cognition Preceding AD in a Biracial Population Sample

> **NIH NIH R01** · RUSH UNIVERSITY MEDICAL CENTER · 2020 · $351,460

## Abstract

This proposal aims to conduct secondary analyses of existing data to examine nonlinear cognitive decline
in standardized global summary of cognition assessed using executive functioning, episodic memory, and
overall global cognition and orientation within the context of a large population-based study of older adults:
Chicago Health and Aging Project (CHAP). More specifically, the four objectives of this proposal are: 1)
Examine Nonlinear Cognitive Decline in Older Blacks and Whites Using Change Point Models in a Random
Sample of 2,948 Participants with AD and non-AD Diagnosis; 2) investigate the Role of Demographic,
Social, Lifestyle, Cardiovascular, and Genetic Risk Factors on Nonlinear Cognitive Decline in Older Blacks
and Whites with AD and non-AD Diagnosis; 3) Identify the Heterogeneity in Nonlinear Cognitive Decline
Using Latent Class Growth Curve Models Using a Population Sample of 7,757 Blacks and Whites with
Multiple Cognitive Assessments; 4) Understand the Role of Demographic, Social, Lifestyle, Cardiovascular,
and Genetic Risk Factors on Latent Class Memberships to Explain Heterogeneity in Nonlinear Cognitive
Decline. Understanding the rate of cognitive decline in older blacks and whites has a topic of considerable
interest. However, most research has focused on linear trajectories in whites with mixed findings among
blacks. Nonlinear cognitive decline based on change points are nonexistent in blacks and the proposed
work can increase our understanding of preclinical phase of AD and non-AD.

## Key facts

- **NIH application ID:** 10319798
- **Project number:** 7R01AG051635-06
- **Recipient organization:** RUSH UNIVERSITY MEDICAL CENTER
- **Principal Investigator:** Kumar B. Rajan
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $351,460
- **Award type:** 7
- **Project period:** 2021-05-25 → 2022-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10319798

## Citation

> US National Institutes of Health, RePORTER application 10319798, Nonlinear Models of Cognition Preceding AD in a Biracial Population Sample (7R01AG051635-06). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10319798. Licensed CC0.

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