# UC Irvine AD Translational Center for Disease Model Resources-NextSeq Supplement

> **NIH NIH U54** · UNIVERSITY OF CALIFORNIA-IRVINE · 2021 · $90,000

## Abstract

Project Summary/Abstract
A key goal of the UCI Model-AD Disease Model Development and Phenotyping Project (DMDPP) is to
characterize the gene expression levels of the new rodent models of sporadic AD being generated by the
consortium during aging. This involves the building of numerous bulk and single-cell RNA-seq libraries for Model-
AD mice. All of these libraries are currently sequenced on an Illumina NextSeq 500 purchased in 2013. As this
instrument is nearing its end-of-life support by Illumina, we are requesting funds to upgrade the Illumina NextSeq
2000 system in order to increase the reliability and throughput of sequencing the bulk and single-cell RNA-seq
libraries produced by UCI Model-AD. The upgrade will ensure the timely sequencing of the RNA-seq libraries for
the characterization of the changes of gene expression during aging in the UCI model-AD rodent models.

## Key facts

- **NIH application ID:** 10320292
- **Project number:** 3U54AG054349-04S3
- **Recipient organization:** UNIVERSITY OF CALIFORNIA-IRVINE
- **Principal Investigator:** FRANK M LAFERLA
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $90,000
- **Award type:** 3
- **Project period:** 2017-09-15 → 2022-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10320292

## Citation

> US National Institutes of Health, RePORTER application 10320292, UC Irvine AD Translational Center for Disease Model Resources-NextSeq Supplement (3U54AG054349-04S3). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10320292. Licensed CC0.

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