# Resource Core

> **NIH NIH P40** · UNIV OF MASSACHUSETTS MED SCH WORCESTER · 2022 · $565,421

## Abstract

Project Summary – Resource Core
 This grant proposes to continue efforts by the Nonhuman Primate Reagent Resource to develop and
distribute immune cell-depleting antibodies for use in nonhuman primate models of disease. Operational aspects
of the Nonhuman Primate Reagent Resource include seven distinct components whose overall goal is to provide
high-quality, safe, effective and affordable antibody reagents for administration to nonhuman primate.
 We will generate new monoclonal antibodies against NHP targets in conventional or transgenic mice, or from
existing cross-reactive antibodies. Cell-depleting or control antibodies will be engineered into “primatized” forms
to minimize immunogenicity in vivo, and modified to fine tune effector function or glycosylation. Existing platforms
will be used for large-scale antibody expression by transient or stable CHO cell transfection, purification and
buffer formulation. Strict release criteria will be employed for antibody products intended for use in animals. A
web-based platform will be used to disseminate information on reagents available and a marketing plan
established to assure reaching all investigators using nonhuman primate models. Meeting the needs of the
research community will be ensured through community outreach and by establishing a program advisory board.
Program effectiveness will be measured by user surveys. A web-based reagent ordering system and a well-
established fulfillment process will be utilized for timely response to reagent requests.
 These resource activities will be integrated with antibody reagent activities supported by other funding
sources.

## Key facts

- **NIH application ID:** 10320748
- **Project number:** 5P40OD028116-03
- **Recipient organization:** UNIV OF MASSACHUSETTS MED SCH WORCESTER
- **Principal Investigator:** Diogo Magnani
- **Activity code:** P40 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $565,421
- **Award type:** 5
- **Project period:** 2020-01-01 → 2024-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10320748

## Citation

> US National Institutes of Health, RePORTER application 10320748, Resource Core (5P40OD028116-03). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10320748. Licensed CC0.

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